Hair_salt
Category
Hair_salt Brand names, Hair_salt Analogs
Hair_salt Brand Names Mixture
No information avaliable
Hair_salt Chemical_Formula
C43H68ClNO11
Hair_salt RX_link
http://www.rxlist.com/cgi/generic/elidel.htm
Hair_salt fda sheet
Hair_salt msds (material safety sheet)
Hair_salt Synthesis Reference
No information avaliable
Hair_salt Molecular Weight
810.453 g/mol
Hair_salt Melting Point
No information avaliable
Hair_salt H2O Solubility
No information avaliable
Hair_salt State
Solid
Hair_salt LogP
5.099
Hair_salt Dosage Forms
Cream
Hair_salt Indication
For treatment of mild to moderate atopic dermatitis.
Hair_salt Pharmacology
Pimecrolimus is a chemical that is used to treat atopic dermatitis (eczema). Atopic dermatitis is a skin condition characterized by redness, itching, scaling and inflammation of the skin. The cause of atopic dermatitis is not known; however, scientists believe that it may be due to activation of the immune system by various environmental or emotional triggers. Scientists do not know exactly how pimecrolimus reduces the manifestations of atopic dermatitis, but pimecrolimus reduces the action of T-cells and mast cells which are part of the immune system and contribute to responses of the immune system. Pimecrolimus prevents the activation of T-cells by blocking the effects of chemicals (cytokines) released by the body that stimulate T-cells. Pimecrolimus also reduces the ability of mast cells to release chemicals that promote inflammation.
Hair_salt Absorption
Because of the low systemic absorption of pimecrolimus following topical application the calculation of standard pharmacokinetic measures such as AUC, Cmax, half-life, etc. cannot be reliably done.
Hair_salt Toxicity
Side effects include burning sensation, irritation, pruritus, erythema, and skin infections, at the application site.
Hair_salt Patient Information
Hair_salt Organisms Affected
Humans and other mammals
