PharmacyCodes



Fomepizol [INN-Spanish] en es it fr

Fomepizol [INN-Spanish] Brand names, Fomepizol [INN-Spanish] Analogs

Fomepizol [INN-Spanish] Brand Names Mixture

  • No information avaliable

Fomepizol [INN-Spanish] Chemical_Formula

C4H6N2

Fomepizol [INN-Spanish] RX_link

http://www.rxlist.com/cgi/generic/antizol.htm

Fomepizol [INN-Spanish] fda sheet

Fomepizol [INN-Spanish] msds (material safety sheet)

Fomepizol_[INN-Spanish] MSDS

Fomepizol [INN-Spanish] Synthesis Reference

No information avaliable

Fomepizol [INN-Spanish] Molecular Weight

82.1039 g/mol

Fomepizol [INN-Spanish] Melting Point

25 oC

Fomepizol [INN-Spanish] H2O Solubility

No information avaliable

Fomepizol [INN-Spanish] State

Liquid

Fomepizol [INN-Spanish] LogP

0.82

Fomepizol [INN-Spanish] Dosage Forms

Liquid

Fomepizol [INN-Spanish] Indication

Antizol is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis

Fomepizol [INN-Spanish] Pharmacology

Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. Ethylene glycol is first metabolized to glycoaldehyde which then undergoes further oxidation to glycolate, glyoxylate, and oxalate. It is glycolate and oxalate that are primarily responsible for the metabolic acidosis and renal damage that are seen in ethylene glycol poisoning. {01}{03} Methanol is first metabolized to formaldehyde and then undergoes subsequent oxidation via formaldehyde dehydrogenase to become formic acid. It is formic acid that is primarily responsible for the metabolic acidosis and visual disturbances that are associated with methanol poisoning.

Fomepizol [INN-Spanish] Absorption

Rapid and complete

Fomepizol [INN-Spanish] side effects and Toxicity

Headache, nausea, dizziness

Fomepizol [INN-Spanish] Patient Information

Fomepizol [INN-Spanish] Organisms Affected

Humans and other mammals