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Cobione Brand names, Cobione Analogs

Cobione Brand Names Mixture

  • Liver-Stomach Concentrate with Intrinsic Factor (Special Liver-Stomach Concentrate + Vitamin B 12 + Iron + Ascorbic Acid + Folic Acid)

Cobione Chemical_Formula


Cobione RX_link

Cobione fda sheet

Cobione msds (material safety sheet)

Cobione MSDS

Cobione Synthesis Reference

No information avaliable

Cobione Molecular Weight

1355.37 g/mol

Cobione Melting Point

> 300 oC

Cobione H2O Solubility

1.25E+004 mg/L

Cobione State


Cobione LogP


Cobione Dosage Forms

Intra-nasal gel; Parenteral (oral)

Cobione Indication

For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency.

Cobione Pharmacology

Vitamin B12 is a water-soluble organometallic compound with a trivalent cobalt ion bound inside a corrin ring. It isneeded for nerve cells and red blood cells, and to make DNA. Vitamin B12 deficiency is the cause of several forms of anemia.

Cobione Absorption

Readily absorbed in the lower half of the ileum.

Cobione side effects and Toxicity

Anaphylactic reaction (skin rash, itching, wheezing)-after parenteral administration. ORL-MUS LD50 > 8000 mg/kg

Cobione Patient Information

Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives. Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord. Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration. A vegetarian diet which contains no animal products (including milk products or eggs) does not supply any vitamin B12. Patients following such a diet, should be advised to take oral vitamin B12 regularly. The need for vitamin B12 is increased by pregnancy and lactation. Deficiency has been recognized in infants of vegetarian mothers who were breast fed, even though the mothers had no symptoms of deficiency at the time.

Cobione Organisms Affected

Humans and other mammals