Chlorothiazide

Chlorothiazide Brand names, Chlorothiazide Analogs

Chlorothiazide Brand Names Mixture

Supres 150 Tab (Chlorothiazide + Methyldopa)
Supres 250 Tab (Chlorothiazide + Methyldopa)

Chlorothiazide Chemical_Formula

C₇H₆ClN₃O₄S₂

Chlorothiazide RX_link

http://www.rxlist.com/cgi/generic2/chloroth.htm

Chlorothiazide fda sheet

Chlorothiazide msds (material safety sheet)

Chlorothiazide MSDS

Chlorothiazide Synthesis Reference

No information avaliable

Chlorothiazide Molecular Weight

295.725 g/mol

Chlorothiazide Melting Point

350 ^oC

Chlorothiazide H₂O Solubility

266 mg/L

Chlorothiazide State

Solid

Chlorothiazide LogP

0.549

Chlorothiazide Dosage Forms

Tablet (250, 500 mg)

Chlorothiazide Indication

Chlorothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.

Chlorothiazide Pharmacology

Like other thiazides, chlorothiazide promotes water loss from the body (diuretics). It inhibits Na⁺/Cl^- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. Chlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic efficacy. Chlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate.

Chlorothiazide Absorption