Chloditan

Chloditan Brand names, Chloditan Analogs

Chloditan Brand Names Mixture

No information avaliable

Chloditan Chemical_Formula

C₁₄H₁₀Cl₄

Chloditan RX_link

http://www.rxlist.com/cgi/generic2/mitotane.htm

Chloditan fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=mitotane

Chloditan msds (material safety sheet)

Chloditan MSDS

Chloditan Synthesis Reference

No information avaliable

Chloditan Molecular Weight

320.04 g/mol

Chloditan Melting Point

77 ^oC

Chloditan H₂O Solubility

0.1 mg/L

Chloditan State

Solid

Chloditan LogP

6.372

Chloditan Dosage Forms

Tablet

Chloditan Indication

For treatment of inoperable adrenocortical tumours; Cushing's syndrome

Chloditan Pharmacology

Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol.

Chloditan Absorption

About 40% oral Lysodren is absorbed

Chloditan side effects and Toxicity