Acetyladriamycin en es it fr

Acetyladriamycin Brand names, Acetyladriamycin Analogs

Acetyladriamycin Brand Names Mixture

  • No information avaliable

Acetyladriamycin Chemical_Formula


Acetyladriamycin RX_link

Acetyladriamycin fda sheet,%20daunomycin

Acetyladriamycin msds (material safety sheet)

Acetyladriamycin MSDS

Acetyladriamycin Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Acetyladriamycin Molecular Weight

527.52 g/mol

Acetyladriamycin Melting Point

208-209 oC

Acetyladriamycin H2O Solubility

39.2 mg/L

Acetyladriamycin State


Acetyladriamycin LogP


Acetyladriamycin Dosage Forms

Powder for solution; Suspension

Acetyladriamycin Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Acetyladriamycin Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Acetyladriamycin Absorption

No information avaliable

Acetyladriamycin side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Acetyladriamycin Patient Information

Acetyladriamycin Organisms Affected

Humans and other mammals