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                      **** MATERIAL SAFETY DATA SHEET ****

  D(-)-PENICILLAMINE, 99+%

        **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****

MSDS Name: D(-)-PENICILLAMINE, 99+%
Catalog Numbers:
     12974-0000, 12974-0050, 12974-0250
Synonyms:
Company Identification (Europe):  Acros Organics BVBA
                                  Janssen Pharmaceuticalaan 3a
                                  2440 Geel, Belgium
Company Identification (USA):     Acros Organics
                                  One Reagent Lane
                                  Fairlawn, NJ  07410
For information in North America, call:   800-ACROS-01
For information in Europe, call:          0032(0) 14575211
For emergencies in the US, call CHEMTREC: 800-424-9300
For emergencies in Europe, call:     0032(0) 14575299

          **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****

+----------------+--------------------------------------+----------+-----------+-----------+---------------+
|      CAS#      |              Chemical Name           |    %     |  EINECS#  |Haz Symbols| Risk Phrases  |
|----------------|--------------------------------------|----------|-----------|-----------|---------------+
|       52-67-5  |D(-)-PENICILLAMINE, 99+%              |   99+%   | 200-148-8 |||
+----------------+--------------------------------------+----------+-----------+-----------+---------------+
          Hazard Symbols: None Listed.
          Risk Phrases: None Listed.

                  **** SECTION 3 - HAZARDS IDENTIFICATION ****

                               EMERGENCY OVERVIEW
Not available.

Potential Health Effects
     Eye:
          May cause eye irritation.
     Skin:
          May cause skin irritation.
     Ingestion:
          May cause irritation of the digestive tract.
     Inhalation:
          May cause respiratory tract irritation.
     Chronic:
          Not available.

                    **** SECTION 4 - FIRST AID MEASURES ****

     Eyes:
          Flush eyes with plenty of water for at least 15 minutes,
          occasionally lifting the upper and lower eyelids. Get medical aid
          immediately.
     Skin:
          Get medical aid. Flush skin with plenty of water for at least 15
          minutes while removing contaminated clothing and shoes.
     Ingestion:
          If victim is conscious and alert, give 2-4 cupfuls of milk or water.
          Get medical aid immediately.
     Inhalation:
          Get medical aid immediately. Remove from exposure and move to fresh
          air immediately. If not breathing, give artificial respiration. If
          breathing is difficult, give oxygen.
     Notes to Physician:

                  **** SECTION 5 - FIRE FIGHTING MEASURES ****

     General Information:
          As in any fire, wear a self-contained breathing apparatus in
          pressure-demand, MSHA/NIOSH (approved or equivalent), and full
          protective gear. During a fire, irritating and highly toxic gases
          may be generated by thermal decomposition or combustion.
     Extinguishing Media:
          Use agent most appropriate to extinguish fire.

                **** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****

     General Information: Use proper personal protective equipment as indicated
                          in Section 8.
     Spills/Leaks:
          Clean up spills immediately, observing precautions in the Protective
          Equipment section.

                   **** SECTION 7 - HANDLING and STORAGE ****

     Handling:
          Wash thoroughly after handling. Remove contaminated clothing and
          wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid
          ingestion and inhalation.
     Storage:
          Store in a cool, dry place. Keep container closed when not in use.

          **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****

     Engineering Controls:
          Use process enclosure, local exhaust ventilation, or other
          engineering controls to control airborne levels.
     Personal Protective Equipment

                 Eyes:
                       Wear chemical goggles.
                 Skin:
                       Wear appropriate protective gloves to prevent skin
                       exposure.
             Clothing:
                       Wear appropriate protective clothing to minimize
                       contact with skin.
          Respirators:
                       A respiratory protection program that meets OSHA's 29
                       CFR 1910.134 and ANSI Z88.2 requirements or European
                       Standard EN 149 must be followed whenever workplace
                       conditions warrant a respirator's use.

             **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****

Physical State:             Crystalline powder
Color:                      white - almost white
Odor:                       Not available.
pH:                         4.5-5.5 (1% aq.sol.)
Vapor Pressure:             Not available.
Viscosity:                  Not available.
Boiling Point:              Not available.
Freezing/Melting Point:     212 deg C
Autoignition Temperature:   Not available.
Flash Point:                Not available.
Explosion Limits, lower:    Not available.
Explosion Limits, upper:    Not available.
Decomposition Temperature:
Solubility in water:        11.1%
Specific Gravity/Density:
Molecular Formula:          C5H11NO2S
Molecular Weight:           149.21

                 **** SECTION 10 - STABILITY AND REACTIVITY ****

     Chemical Stability:
          Stable under normal temperatures and pressures.
     Conditions to Avoid:
          Incompatible materials.
     Incompatibilities with Other Materials:
          Strong oxidizing agents.
     Hazardous Decomposition Products:
          Irritating and toxic fumes and gases.
     Hazardous Polymerization: Has not been reported

                **** SECTION 11 - TOXICOLOGICAL INFORMATION ****

     RTECS#:
          CAS# 52-67-5: YV9425000
     LD50/LC50:
          CAS# 52-67-5: Oral, mouse: LD50 = 720 mg/kg; Oral, rat: LD50 = 6170
          mg/kg.
     Carcinogenicity:
       D(-)-PENICILLAMINE, 99+% -
          Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
          See actual entry in RTECS for complete information.

                  **** SECTION 12 - ECOLOGICAL INFORMATION ****



                 **** SECTION 13 - DISPOSAL CONSIDERATIONS ****

Dispose of in a manner consistent with federal, state, and local regulations.

                  **** SECTION 14 - TRANSPORT INFORMATION ****

     IATA
          No information available.
     IMO
          No information available.
     RID/ADR
          No information available.

                  **** SECTION 15 - REGULATORY INFORMATION ****

 European/International Regulations
     European Labeling in Accordance with EC Directives
          Hazard Symbols: Not available.
          Risk Phrases:
          Safety Phrases:
                       S 24/25  Avoid contact with skin and eyes.
   WGK (Water Danger/Protection)
          CAS# 52-67-5:
   United Kingdom Occupational Exposure Limits

   United Kingdom Maximum Exposure Limits

   Canada
          None of the chemicals in this product are listed on the DSL/NDSL list.
          CAS# 52-67-5 is not listed on Canada's Ingredient Disclosure List.
   Exposure Limits
 US FEDERAL
     TSCA
          CAS# 52-67-5 is not listed on the TSCA inventory.
          It is for research and development use only.

                  **** SECTION 16 - ADDITIONAL INFORMATION ****

     MSDS Creation Date:  7/16/1996  Revision #0 Date: Original.

     The information above is believed to be accurate and represents the best
     information currently available to us. However, we make no warranty of
     merchantability or any other warranty, express or implied, with respect to
     such information, and we assume no liability resulting from its use. Users
     should make their own investigations to determine the suitability of the
     information for their particular purposes. In no way shall the company be
     liable for any claims, losses, or damages of any third party or for lost
     profits or any special, indirect, incidental, consequential or exemplary
     damages, howsoever arising, even if the company has been advised of
     the possibility of such damages.
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