uPA
uPA Brand names, uPA Analogs
uPA Brand Names Mixture
- No information avaliable
uPA Chemical_Formula
C1376H2145N383O406S18
uPA RX_link
http://www.rxlist.com/cgi/pharmclips2.cgi?keyword=%20Abbokinase%AE
uPA fda sheet
uPA msds (material safety sheet)
uPA Synthesis Reference
PMID 2987867
uPA Molecular Weight
31126.5
uPA Melting Point
76 oC at pH 4.5 (Nowak, U.K. et al., Biochemistry 33:2951-2960 (1994).
uPA H2O Solubility
No information avaliable
uPA State
Liquid
uPA LogP
-0.466
uPA Dosage Forms
Powder for solution; Solution (IV infusion)
uPA Indication
For the treatment of pulminary embolism, coronary artery thrombosis and IV catheter clearance
uPA Pharmacology
Urokinase is used for the treatment of pulmonary embolisms. The low molecular weight form of human urokinase consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Urokinase is an enzyme (protein) produced by the kidney, and found in the urine. There are two forms of urokinase which differ in molecular weight but have similar clinical effects. Urokinase is the low molecular weight form. Urokinase acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen and some other plasma proteins.
uPA Absorption
No information avaliable
uPA side effects and Toxicity
No information avaliable
uPA Patient Information
http://www.drugs.com/PDR/Abbokinase.html
uPA Organisms Affected
Humans and other mammals
