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MSDS Language: EN
Country:
                      **** MATERIAL SAFETY DATA SHEET ****

  Estrone, 99+%

        **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****

MSDS Name: Estrone, 99+%
Catalog Numbers:
     11784-0000, 11784-0010, 11784-0050
Synonyms:
Company Identification (Europe):  Acros Organics BVBA
                                  Janssen Pharmaceuticalaan 3a
                                  2440 Geel, Belgium
Company Identification (USA):     Acros Organics
                                  One Reagent Lane
                                  Fairlawn, NJ  07410
For information in North America, call:   800-ACROS-01
For information in Europe, call:          0032(0) 14575211
For emergencies in the US, call CHEMTREC: 800-424-9300
For emergencies in Europe, call:     0032(0) 14575299

          **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****

+----------------+--------------------------------------+----------+-----------+-----------+---------------+
|      CAS#      |              Chemical Name           |    %     |  EINECS#  |Haz Symbols| Risk Phrases  |
|----------------|--------------------------------------|----------|-----------|-----------|---------------+
|       53-16-7  |Estrone                               |   99+%   | 200-164-5 |||
+----------------+--------------------------------------+----------+-----------+-----------+---------------+
          Hazard Symbols: XN
          Risk Phrases: 40

                  **** SECTION 3 - HAZARDS IDENTIFICATION ****

                               EMERGENCY OVERVIEW
Limited evidence of a carcinogenic effect. Possible risk of impaired
fertility. Possible risk of harm to the unborn child.

Potential Health Effects
     Eye:
          May cause eye irritation.
     Skin:
          May cause skin irritation. May be harmful if absorbed through the
          skin.
     Ingestion:
          May cause irritation of the digestive tract. May be harmful if
          swallowed. Ingestion of large amounts may cause nausea, vomiting,
          diarrhea, and abdominal discomort. Ingestion may cause a decrease in
          blood pressure, rapid pulse and visual disturbances.
     Inhalation:
          May cause respiratory tract irritation. May be harmful if inhaled.
     Chronic:
          Possible risk of irreversible effects.

                    **** SECTION 4 - FIRST AID MEASURES ****

     Eyes:
          Flush eyes with plenty of water for at least 15 minutes,
          occasionally lifting the upper and lower eyelids. Get medical aid.
     Skin:
          Get medical aid. Flush skin with plenty of water for at least 15
          minutes while removing contaminated clothing and shoes.
     Ingestion:
          Get medical aid. Wash mouth out with water.
     Inhalation:
          Remove from exposure and move to fresh air immediately. If not
          breathing, give artificial respiration. If breathing is difficult,
          give oxygen. Get medical aid.
     Notes to Physician:
          Treat symptomatically and supportively.

                  **** SECTION 5 - FIRE FIGHTING MEASURES ****

     General Information:
          As in any fire, wear a self-contained breathing apparatus in
          pressure-demand, MSHA/NIOSH (approved or equivalent), and full
          protective gear. Dusts at sufficient concentrations can form
          explosive mixtures with air.
     Extinguishing Media:
          Use water spray, dry chemical, carbon dioxide, or chemical foam.

                **** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****

     General Information: Use proper personal protective equipment as indicated
                          in Section 8.
     Spills/Leaks:
          Vacuum or sweep up material and place into a suitable disposal
          container. Avoid generating dusty conditions.

                   **** SECTION 7 - HANDLING and STORAGE ****

     Handling:
          Use with adequate ventilation. Minimize dust generation and
          accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid
          contact with skin and eyes. Take precautionary measures against
          static discharges.
     Storage:
          Store in a tightly closed container. Store in a dry area. Hormones
          and antibiotics room. Store protected from light. Store at room
          temperature.

          **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****

     Engineering Controls:
          Use adequate ventilation to keep airborne concentrations low.
     Personal Protective Equipment

                 Eyes:
                       Wear chemical goggles.
                 Skin:
                       Wear appropriate protective gloves to prevent skin
                       exposure.
             Clothing:
                       Wear appropriate protective clothing to prevent skin
                       exposure.
          Respirators:
                       Follow the OSHA respirator regulations found in 29
                       CFR 1910.134 or European Standard EN 149. Always use
                       a NIOSH or European Standard EN 149 approved
                       respirator when necessary.

             **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****

Physical State:             Crystals
Color:                      white to almost white
Odor:                       odorless
pH:                         Not available.
Vapor Pressure:             Not available.
Viscosity:                  Not available.
Boiling Point:              Not available.
Freezing/Melting Point:     258-261 deg C (dec)
Autoignition Temperature:   Not available.
Flash Point:                Not available.
Explosion Limits, lower:    Not available.
Explosion Limits, upper:    Not available.
Decomposition Temperature:
Solubility in water:        0.03 g/l water
Specific Gravity/Density:
Molecular Formula:          C18H22O2
Molecular Weight:           270.36

                 **** SECTION 10 - STABILITY AND REACTIVITY ****

     Chemical Stability:
          Stable under normal temperatures and pressures.
     Conditions to Avoid:
          Incompatible materials, light.
     Incompatibilities with Other Materials:
          Strong oxidizing agents.
     Hazardous Decomposition Products:
          Carbon monoxide, carbon dioxide.
     Hazardous Polymerization: Will not occur.

                **** SECTION 11 - TOXICOLOGICAL INFORMATION ****

     RTECS#:
          CAS# 53-16-7: KG8575000
     LD50/LC50:
          Not available.
     Carcinogenicity:
       Estrone -
          California: carcinogen; initial date 1/1/88
                OSHA: Possible Select carcinogen
          See actual entry in RTECS for complete information.

                  **** SECTION 12 - ECOLOGICAL INFORMATION ****

     Other
          Avoid entering into waters or underground water.

                 **** SECTION 13 - DISPOSAL CONSIDERATIONS ****

Dispose of in a manner consistent with federal, state, and local regulations.

                  **** SECTION 14 - TRANSPORT INFORMATION ****

     IATA
          No information available.
     IMO
          No information available.
     RID/ADR
          No information available.

                  **** SECTION 15 - REGULATORY INFORMATION ****

 European/International Regulations
     European Labeling in Accordance with EC Directives
          Hazard Symbols: XN
          Risk Phrases:
                       R 40  Limited evidence of a carcinogenic effect.
                       R 62  Possible risk of impaired fertility.
                       R 63  Possible risk of harm to the unborn child.
          Safety Phrases:
                       S 36/37  Wear suitable protective clothing and
                       gloves.
                       S 45  In case of accident or if you feel unwell, seek
                       medical advice immediately (show the label where
                       possible).
   WGK (Water Danger/Protection)
          CAS# 53-16-7: 2
   United Kingdom Occupational Exposure Limits

   United Kingdom Maximum Exposure Limits

   Canada
          CAS# 53-16-7 is listed on Canada's NDSL List.
          CAS# 53-16-7 is not listed on Canada's Ingredient Disclosure List.
   Exposure Limits
 US FEDERAL
     TSCA
          CAS# 53-16-7 is listed on the TSCA inventory.

                  **** SECTION 16 - ADDITIONAL INFORMATION ****

     MSDS Creation Date:  7/16/1996  Revision #1 Date:  4/28/2000

     The information above is believed to be accurate and represents the best
     information currently available to us. However, we make no warranty of
     merchantability or any other warranty, express or implied, with respect to
     such information, and we assume no liability resulting from its use. Users
     should make their own investigations to determine the suitability of the
     information for their particular purposes. In no way shall the company be
     liable for any claims, losses, or damages of any third party or for lost
     profits or any special, indirect, incidental, consequential or exemplary
     damages, howsoever arising, even if the company has been advised of
     the possibility of such damages.
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