Suprane

Material Safety Data Sheet
L(-)-Epinephrine, 99%

ACC# 96863
Section 1 - Chemical Product and Company Identification
MSDS Name: L(-)-Epinephrine, 99%
Catalog Numbers: AC204400000, AC204400050, AC204400100
Synonyms:
l-3,4-Dihydroxy-Alpha-(Methylaminomethyl)Benzyl Alcohol; Adrenaline
Company Identification:

              Acros Organics N.V.
              One Reagent Lane
              Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
51-43-4 L(-)-Epinephrine 99 200-098-7

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: white to light beige crystalline powder.
Warning! Harmful if swallowed, inhaled, or absorbed through the skin. Causes eye, skin, and respiratory tract irritation. May cause central nervous system effects. May cause central nervous system depression. Light sensitive. Air sensitive. May cause cardiac disturbances. The toxicological properties of this material have not been fully investigated.
Target Organs: Central nervous system, respiratory system, cardiovascular system, eyes, skin.


Potential Health Effects
Eye: Causes eye irritation. At high concentrations may cause lacrimation (tearing) and irritation. May cause chemical conjunctivitis.
Skin: Causes skin irritation. May be absorbed through the skin in harmful amounts.
Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause cardiac disturbances. The toxicological properties of this substance have not been fully investigated. May cause central nervous system depression. May be harmful if swallowed.
Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled. May cause cardiac damage. Can produce delayed pulmonary edema. Inhalation at high concentrations may cause CNS depression and asphixiation.
Chronic: Effects may be delayed.

Section 4 - First Aid Measures


Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Containers may explode in the heat of a fire. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers.
Flash Point: Not available.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 2; Flammability: 0; Instability: 1

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Provide ventilation. Place under an inert atmosphere.

Section 7 - Handling and Storage


Handling: Wash thoroughly after handling. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light. Handle under an inert atmosphere. Store protected from air. Wash clothing before reuse.
Storage: Keep refrigerated. (Store below 4C/39F.) Store in a tightly closed container. Poison room locked/refrigerator. Do not expose to air. Store protected from light. Store under an inert atmosphere.

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
L(-)-Epinephrine none listed none listed none listed

OSHA Vacated PELs: L(-)-Epinephrine: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear safety glasses and chemical goggles if splashing is possible.
Skin: Wear appropriate protective gloves and clothing to prevent skin exposure.
Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators: Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.

Section 9 - Physical and Chemical Properties


Physical State: Crystalline powder
Appearance: white to light beige
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:208-211 deg C
Decomposition Temperature:> 212 deg C
Solubility: slightly soluble
Specific Gravity/Density:Not available.
Molecular Formula:C9H13NO3
Molecular Weight:183.21

Section 10 - Stability and Reactivity


Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials, light, exposure to air, excess heat.
Incompatibilities with Other Materials: Acid chlorides, acids, oxidizing agents.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information


RTECS#:      
CAS# 51-43-4: DO2625000
LD50/LC50:
CAS# 51-43-4:
     Skin, rat: LD50 = 62 mg/kg;
.

Carcinogenicity:
CAS# 51-43-4: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No information found
Teratogenicity: No information found
Reproductive Effects: Adverse reproductive effects have occurred in experimental animals.
Mutagenicity: Mutagenic effects have occurred in experimental animals.
Neurotoxicity: No information found
Other Studies:

Section 12 - Ecological Information


Ecotoxicity: No data available. No information available.
Environmental: Terrestrial: No information found in the available literature however, Epinephrine should be highly mobile in soils, and it may leach to ground water. However, it is unstable in the presence of light, heat, air and alkalies so it has the potential to undergo direct photolysis and various chemical reactions in the soil. Aquatic Fate: None located in the available literature however, expected to undergo changes similar to those expected in soil. Atmospheric Fate: Expected to exist almost entirely in the particulate phase in ambient air. It has an estimated half-life of about three hours.
Physical: No information available.
Other: No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: CAS# 51-43-4: waste number P042.
RCRA U-Series: None listed.

Section 14 - Transport Information

US DOT Canada TDG
Shipping Name: DOT regulated - small quantity provisions apply (see 49CFR173.4) TOXIC SOLID ORGANIC NOS (EPINEPHRINE)
Hazard Class: 6.1
UN Number: UN2811
Packing Group: II

Section 15 - Regulatory Information

US FEDERAL

TSCA
     CAS# 51-43-4 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     CAS# 51-43-4: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 51-43-4: immediate, delayed.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 51-43-4 can be found on the following state right to know lists: New Jersey, Pennsylvania, Massachusetts.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
     T
Risk Phrases:

     R 23/24/25 Toxic by inhalation, in contact with skin and if
     swallowed.
     R 33 Danger of cumulative effects.
     R 36/37/38 Irritating to eyes, respiratory system and skin.

Safety Phrases:

     S 23 Do not inhale gas/fumes/vapour/spray.
     S 26 In case of contact with eyes, rinse immediately with plenty of
     water and seek medical advice.
     S 36/37/39 Wear suitable protective clothing, gloves and eye/face pr
     otection.
     S 45 In case of accident or if you feel unwell, seek medical advice
     immediately (show the label where possible).

WGK (Water Danger/Protection)

     CAS# 51-43-4: 3
Canada - DSL/NDSL
     CAS# 51-43-4 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of D1A, D2B.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List

Section 16 - Additional Information

MSDS Creation Date: 9/02/1997
Revision #8 Date: 1/31/2005

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.