Sumatriptan Succinate

GLAXO INC -- IMITREX -- 6505-01-374-5873
=====================  Product Identification  =====================

Product ID:IMITREX
MSDS Date:02/02/1993
FSC:6505
NIIN:01-374-5873
MSDS Number: BVQHB
=== Responsible Party ===
Company Name:GLAXO INC
Address:5 MOORE DR
City:RESEARCH TRIANGLE PARK
State:NC
ZIP:27709
Country:US
Info Phone Num:919-248-2100
Emergency Phone Num:919-248-2100/2700
CAGE:34006
=== Contractor Identification ===
Company Name:GLAXO WELLCOME INC.
Address:5 MOORE DR
Box:13398
City:DURHAM
State:NC
ZIP:27709
Country:US
Phone:919-248-2100
CAGE:34006

=============  Composition/Information on Ingredients  =============

Ingred
    Name:3-(2-(DIMETHYLAMINO)ETHYL)-N-METHYL-1H-INDOLE-5-METHANESULFONA
    MIDE WITH SUCCINIC ACID(1:1)
CAS:103628-48-4
Other REC Limits:15MG/M3

=====================  Hazards Identification  =====================

Routes of Entry: Inhalation:YES  Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:INTRAVENOUS/INHAL/INGEST:MAY CAUSE
    ELEVATED SYSTOLIC BLOOD PRESSURE.
Explanation of Carcinogenicity:THERE ARE NO INGREDIENTS ABOVE 0.1%
    WHICH ARE IDENTIFIED AS CARCINOGENS BY NTP,IARC OR OSHA.
Effects of Overexposure:INTRAVENOUS/INGEST/INHAL:MAY CAUSE CHEST
    PAIN(ANGINA),TREMOR,LACK OF COORDINATION,DILATION OF PUPILS AND
    BLOOD VESSELS,SALIVATION,INCREASED HEART AND BREATHING RATES.
Medical Cond Aggravated by Exposure:PERSONS WITH PRE-EXISTING HEART
    AILMENTS(HIGH BLOOD PRESSURE,CORONARY DISEASE) MAY BE AT INCREASED
    RISK FROM EXPOSURE.

=======================  First Aid Measures  =======================

First Aid:SKIN:REMOVE CONTAMINATED CLOTHING;WASH WITH SOAP AND
    WATER.EYES:FLUSH WITH WATER FOR 15 MINUTES.INHAL:REMOVE TO FRESH
    AIR.GIVE OXYGEN OR ARTIFICIAL RESPIRATION IF NEEDED.INGEST:DO NOT
    INDUCE VOMITING. GET PROMPT QUALIFIED MEDICAL ATTENTION.IF
    CONSCIOUS,RINSE MOUTH WITH WATER.

=====================  Fire Fighting Measures  =====================

Flash Point:NONE
Extinguishing Media:WATER SPRAY,MULTI-PURPOSE DRY CHEMICAL.
Fire Fighting Procedures:USE A SELF-CONTAINED BREATHING APPARATUS AND
    FULL PROTECTIVE EQUIPMENT.
Unusual Fire/Explosion Hazard:THE FINELY DISPURSED DUST FROM THIS
    PRODUCT IS A FIRE OR EXPLOSION HAZARD IN THE PRESENCE OF SOURCES OF
    IGNITION.

==================  Accidental Release Measures  ==================

Spill Release Procedures:USE PROPER PROTECTIVE AND RESPIRATORY
    EQUIPMENT.SWEEP OR VACUUM WITH A HEPA VACUUM.DO NOT STIR UP
    DUST.PLACE IN AN APPROPRIATE CONTAINER FOR DISPOSAL.CLEAN SPILL
    AREA.
Neutralizing Agent:NONE

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN A COOL,DRY,WELL-VENTILATED
    PLACE.KEEP CONTAINER CLOSED WHEN NOT IN USE.AVOID CREATING DUST.
Other Precautions:FOLLOW LABEL DIRECTIONS.AVOID BREATHING DUST.AVOID
    SKIN AND EYE CONTACT.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WHERE ENVIRONMENTAL CONTROLS ARE LACKING OR IN
    ENCLOSED SPACES USE A NIOSH/MSHA APPROVED RESPIRATOR FOR DUST.
Ventilation:USE LOCAL EXHAUST.
Protective Gloves:IMPERVIOUS
Eye Protection:DUST-PRROF GOGGLES.
Other Protective Equipment:PROTECTIVE CLOTHING,AS NEEDED.PROVIDE A
    LOCAL EYE WASH STATION AND SAFETY SHOWER.
Work Hygienic Practices:USE REASONABLE CARE IN HANDLING THIS
    PRODUCT.WASH HANDS AFTER USE AND BEFORE EATING.
Supplemental Safety and Health
TIR REPORTS THAT THIS ITEM IS CONTAINED IN A SYRINGE AT 6MG/0.5ML AND
    THAT THE SYRINGE CONTAINS 1 ML.WORKERS EXPOSED TO DUST SHOULD
    CHANGE CLOTHES AND SHOWER.

==================  Physical/Chemical Properties  ==================

HCC:N1
Melt/Freeze Pt:M.P/F.P Text:329F,165C
Solubility in Water:APPRECIABLE
Appearance and Odor:POWDER;WHITE TO OFF-WHITE.ODOR NOT REPORTED.TIR
    REPORTS ITEM IS IN A SYRINGE.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
MANUFACTURER STATES NONE KNOWN.
Stability Condition to Avoid:HIGH HEAT;DECOMPOSES ENDOTHERMICALLY(TAKES
    IN HEAT).
Hazardous Decomposition Products:CORROSIVE OXIDES OF NITROGEN AND
    SULFUR.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE WITH FEDERAL,STATE AND
    LOCAL REGULATIONS.MFR SUGGESTS INCINERATION.

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