Pynastin

Pindolol, 97%
Product Number:  284106
Product Name:  Pindolol, 97%
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Valid 08/2001 - 10/2001

Aldrich Chemical Co., Inc.
1001 West St. Paul
Milwaukee, WI 53233 USA
Tel: 414-273-3850





             M A T E R I A L  S A F E T Y  D A T A  S H E E T
             
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
    CATALOG #:            284106
    NAME:                 PINDOLOL, 97%
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
    CAS #: 13523-86-9
    MF: C14H20N2O2
    EC NO:  236-867-9
  SYNONYMS
    CARVISKEN * 4-(2-HYDROXY-3-ISOPROPYLAMINOPROPOXY)-INDOLE * DL-4-(2-
    HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)INDOLE * (+-)-4-(2-HYDROXY-3-
    (ISOPROPYLAMINO)PROPOXY)INDOLE * 1-(4-INDOLYLOXY)-3-(ISOPROPYLAMINO)-
    2-PROPANOL * 1-(1H-INDOL-4-YLOXY)-3-((1-METHYLETHYL)AMINO)-2-PROPANOL
    * 4-(3-(ISOPROPYLAMINO)-2-HYDROXYPROPOXY)INDOLE * LB 46 * DL-LB 46 *
    (+-)-LB 46 * 1-((1-METHYLETHYL)AMINO)-3-(4-INDOLYLOXY)-2-PROPANOL *
    DL-PINDOLOL * DL-PINDOLOL * DL-PINDOLOL * (RS)-PINDOLOL * (+-)-
    PINDOLOL * PRINODOLOL * 2-PROPANOL, 1-(4-INDOLYLOXY)-3-
    (ISOPROPYLAMINO)- * VISKEN *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
  LABEL PRECAUTIONARY STATEMENTS
    TOXIC (USA)
    HARMFUL (EU)
    HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
    IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
    TARGET ORGAN(S):
    HEART
    LUNGS
    IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
    WATER AND SEEK MEDICAL ADVICE.
    WEAR SUITABLE PROTECTIVE CLOTHING.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
    IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
    CALL A PHYSICIAN.
    IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
    RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
    IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
    SHOES. CALL A PHYSICIAN.
    IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
    THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
  EXTINGUISHING MEDIA
    WATER SPRAY.
    CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
  SPECIAL FIREFIGHTING PROCEDURES
    WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
    PREVENT CONTACT WITH SKIN AND EYES.
  UNUSUAL FIRE AND EXPLOSIONS HAZARDS
    EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
    WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY
    RUBBER GLOVES.
    SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
    AVOID RAISING DUST.
    VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
    REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
    SAFETY SHOWER AND EYE BATH.
    MECHANICAL EXHAUST REQUIRED.
    DO NOT BREATHE DUST.
    AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
    AVOID PROLONGED OR REPEATED EXPOSURE.
    NIOSH/MSHA-APPROVED RESPIRATOR.
    COMPATIBLE CHEMICAL-RESISTANT GLOVES.
    CHEMICAL SAFETY GOGGLES.
    STORE IN A COOL DRY PLACE.
    KEEP TIGHTLY CLOSED.
    WASH THOROUGHLY AFTER HANDLING.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
  APPEARANCE AND ODOR
    WHITE POWDER
  PHYSICAL PROPERTIES
    MELTING POINT:      167 C TO 171 C
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
  STABILITY
    STABLE.
  HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
    CARBON MONOXIDE, CARBON DIOXIDE
    NITROGEN OXIDES
  HAZARDOUS POLYMERIZATION
    WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
  ACUTE EFFECTS
    CAUSES SKIN IRRITATION.
    CAUSES EYE IRRITATION.
    MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
    RESPIRATORY TRACT.
    HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN.
    ADVERSE REACTIONS: HYPERHIDROSIS, BRADYCARDIA, CLAUDICATION, HEART
    BLOCK, HYPOTENSION, SYNCOPE, TACHYCARDIA, DIARRHEA, VOMITING,
    WHEEZING, IMPOTENCE, POLLAKIURIA, AGRANULOCYTOSIS, THROMBOCYTOPENIC
    AND NON-THROMBOCYTOPENIC PURPURA, LARYNGOSPASM, ISCHEMIC COLITIS,
    MESENTERIC ARTERIAL THROMBOSIS, REVERSIBLE ALOPECIA.
  RTECS #: UB6660000
    2-PROPANOL, 1-(1H-INDOL-4-YLOXY)-3-((1-METHYLETHYL)AMINO)-
  TOXICITY DATA
    ORL-RAT LD50:263 MG/KG                        NIGZAY 84,438,1970
    IPR-RAT LD50:110 MG/KG                        IYKEDH 4,90,1973
    SCU-RAT LD50:251 MG/KG                        NIGZAY 84,438,1970
    IVN-RAT LD50:51 MG/KG                         NIGZAY 84,438,1970
    ORL-MUS LD50:235 MG/KG                        JTSCDR 6,301,1981
    IPR-MUS LD50:80 MG/KG                         YACHDS 9,3573,1981
    SCU-MUS LD50:336 MG/KG                        NIGZAY 84,438,1970
    IVN-MUS LD50:22600 UG/KG                      ARZNAD 28,794,1978
    ORL-RBT LD50:650 MG/KG                        NIGZAY 84,438,1970
    IVN-RBT LD50:10 MG/KG                         NIGZAY 84,438,1970
  TARGET ORGAN DATA
    SENSE ORGANS AND SPECIAL SENSES (MYDRIASIS)
    BEHAVIORAL (SOMNOLENCE)
    BEHAVIORAL (TREMOR)
    BEHAVIORAL (CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD)
    BEHAVIORAL (ATAXIA)
    LUNGS, THORAX OR RESPIRATION (DYSPNAE)
    LUNGS, THORAX OR RESPIRATION (RESPIRATORY DEPRESSION)
    ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
    (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
    COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
    DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
    DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
    CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
    OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
    CONTACT ALDRICH CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
  EUROPEAN INFORMATION
    HARMFUL
    R 20/21/22
    HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
    R 36/37/38
    IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
    S 36
    WEAR SUITABLE PROTECTIVE CLOTHING.
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
    THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
    BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
    FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
    OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
    PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
    COPYRIGHT 2001 SIGMA-ALDRICH CO.
    LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY