Pentamidine Isethionate

FUJISAWA INC (FORMERLY LYPHOMED INC) -- PENTAMIDINE ISETHIONATE -- 6505-00F039436
=====================  Product Identification  =====================

Product ID:PENTAMIDINE ISETHIONATE
MSDS Date:02/17/1988
FSC:6505
NIIN:00F039436
MSDS Number: BWWYV
=== Responsible Party ===
Company Name:FUJISAWA INC (FORMERLY LYPHOMED INC)
Address:2020 RUBY
City:MELROSE PARK
State:IL
ZIP:60160-5000
Country:US
Info Phone Num:708-450-7569/7500
Emergency Phone Num:708-450-7569/7500
CAGE:GO395
=== Contractor Identification ===
Company Name:FUJISAWA INC (FORMERLY LYPHOMED INC)
Address:2020 RUBY
City:MELROSE PARK
State:IL
ZIP:60160-5000
Country:US
Phone:708-450-7569/7500
CAGE:GO395
Company Name:LYPHOMED INC  DIV OF FUJISAWA USA INC
Address:2020 RUBY ST
Box:City:MELROSE PARK
State:IL
ZIP:60160-1112
Country:US
Phone:312-345-6170
CAGE:60567

=============  Composition/Information on Ingredients  =============

Ingred Name:PENTAMIDINE ISETHIONATE
CAS:140-64-7
RTECS #:CV6500000

=====================  Hazards Identification  =====================

Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:SEVERE ADVERSE REACTIONS HAVE BEEN
    REPORTED SUCH AS: CARDIA ARRHYTHMIAS/DIABETES MELLITUS/ELEVATED
    SERUM CREATININE/STERILE
    ABSCESS/LEUKOPENIA/HYPOGLYCEMIA/HYPOTENSION/ACUTE RENAL
    FAILURE/HYPOCALCEMIA /STEVENS-JOHNSON SYNDROME/VENTRICULAR
    TACHYCARDIA/INDURATION AT THE SITE OF IM INJECTION/ELEVATED LIVER
    FUNCTION (SUPP)
Explanation of Carcinogenicity:NONE
Effects of Overexposure:PAIN, NAUSEA, ANOREXIA, HYPOTENSION, FEVER,
    RASH, BAD TASTE IN MOUTH, CONFUSION/HALLUCINATIONS, DIZZINESS,
    DIARRHEA

=======================  First Aid Measures  =======================

First Aid:INHALATION: REMOVE TO FRESH AIR. INGESTION: FLUSH MOUTH OUT
    W/WATER. SKIN/EYES: FLUSH W/WATER. OBTAIN MEDICAL ATTENTION IN ALL
    CASES.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:DRY CHEMICAL, CO2/FOAM AS APPROPRIATE FOR
    SURROUNDING FIRE & MATERIALS.
Fire Fighting Procedures:USE SELF CONTAINED BREATHING APPARATUS &
    PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:COMBUSTIBLE. EMITS TOXIC FUMES WHEN
    HEATED TO DECOMPOSITION.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR PERSONAL PROTECTIVE EQUIPMENT. VACUUM
    W/VACUUM CLEANER HAVING A HIGH EFFICIENCY PARTICULATE (HEPA)
    FILTER/ABSORB LIQUID W/PAPER TOWELS. WIPE WORKING SURFACES TO
    DRYNESS, THEN WASH W/SOAP & WATER.

======================	Handling and Storage  ======================

Handling and Storage Precautions:DRY POWDER MATERIAL IS ASSUMED TO BE
    COMBUSTIBLE. GROUND MECHANICAL EQUIPMENT IN CONTACT W/DRY MATERIAL
    TO DISSIPATE BUILDUP OF STATIC ELECTRICITY.
Other Precautions:WHEN HANDLING PHARMACEUTICAL PRODUCTS, AVOID ALL
    CONTACT & INHALATION OF DUST, FUMES, MISTS/VAPORS ASSOCIATED W/THE
    PRODUCT.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:USE NIOSH APPROVED RESPIRATOR
Ventilation:LOCAL EXHAUST
Protective Gloves:DISPOSABLE SURGICAL LATEX
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:DISPOSABLE PROTECTIVE APPAREL
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
    REUSE.
Supplemental Safety and Health
PENTAM 300 (STERILE PENTAMIDINE ISETHIONATE) IS A WHITE, NONPYROGENIC,
    LYOPHILIZED POWDER. HEALTH HAZ CONT'D: ANEMIA, NEURALGIA,
    THROMBOCYTOPENIA, HYPERKALEMIA, PHLEBITIS. ONE PATIENT OUT OF 424
    DEVEL OPED THE FOLLOWING ADVERSE REACTIONS: HYPOCALCEMIA,
    BRONCHOSPASM, HYPERGLYCEMIA.

==================  Physical/Chemical Properties  ==================

Solubility in Water:COMPLETE
Appearance and Odor:WHITE, LYOPHILIZED POWDER W/NO ODOR

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:LIGHT, HEAT
Hazardous Decomposition Products:TOXIC FUMES

====================  Disposal Considerations  ====================

Waste Disposal Methods:WASTE SHOULD BE DISPOSED OF IN ACCORDANCE
    W/LOCAL, STATE & FEDERAL REGULATIONS.

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