Nu-Loperamide

UNITED STATES PHARMACOPEIAL CONVENTION INC -- 37000 LOPERAMIDE HYDROCHLORIDE 200 MG -- 6850-00F055437
=====================  Product Identification  =====================

Product ID:37000 LOPERAMIDE HYDROCHLORIDE 200 MG
MSDS Date:03/11/1997
FSC:6850
NIIN:00F055437
MSDS Number: CGJHQ
=== Responsible Party ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Info Phone Num:301-881-0666
Emergency Phone Num:301-881-0666
Preparer's Name:JEROME HALPERIN
CAGE:14128
=== Contractor Identification ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
Box:City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Phone:301-881-0666
CAGE:14128

=============  Composition/Information on Ingredients  =============

Ingred Name:LOPERAMIDE HYDROCHLORIDE   *97-4*
CAS:34552-83-5
RTECS #:TM4960000

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50(MOUSE): 105 MG/KG
Routes of Entry: Inhalation:YES  Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:INHALATION: MAY CAUSE RESPIRATORY
    TRACT IRRITATION. POSSIBLE HYPERSENSITIZATION & DEHYDRATION.
    EYES/SKIN: IRRITATION. INGESTION: GASTROINTESTINAL IRRITANT.
    POSSIBLE ALLERGIC REACTION TO MATERIAL IF IN HALED, INGESTED/IN
    CONTACT W/SKIN. CNS DEPRESSION MAY OCCUR BY OVERDOSE. USUAL ORAL
    ADULT DOSE IS 4-8 MG/PER DAY.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:BLOATING, ADDOMINAL PAIN, NAUSEA, VOMITING,
    DIZZINESS, DRY MOUTH, SKIN RASH, DROWSINESS, CONSTIPATION,
    DEHYDRATION, IRRITATION
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY TO THE MATERIAL,
    DEHYDRATION, SEVERE COLITIS, ANTIBIOTIC ASSOCIATED DIARRHEA/ACUTE
    DYSENTERY.

=======================  First Aid Measures  =======================

First Aid:INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE
    CPR/OXYGEN IF NECESSARY. SKIN/EYES: FLUSH W/COPIOUS QUANTITIES OF
    WATER. INGESTION: FLUSH OUT MOUTH W/WATER. OBTAIN MEDICAL ATTENTION
    IN ALL CAS ES. OVERDOSE TREATMENT: 1) PROLONGED/CAREFUL MONITORING.
    2)PROMPT ADMINISTRATION OF ACTIVATED CHARCOAL FOLLOWING INGESTION.
    3) GASTRIC LAVAGE IF VOMITING. 4)SUPPORT RESPIRATION. 5) USE
    NALOXONE.

=====================  Fire Fighting Measures  =====================

Lower Limits:<15 G/CUM
Extinguishing Media:WATER SPRAY, DRY CHEMICAL, CO2/FOAM AS APPROPRIATE
    FOR SURROUNDING FIRE & MATERIALS
Fire Fighting Procedures:EVACUATE PERSONNEL TO A SAFE AREA. USE SELF
    CONTAINED BREATHING EQUIPMENT & PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:AS W/ALL DRY POWDERS IT IS ADVISABLE TO
    GROUND MECHANICAL EQUIPMENT IN CONTACT W/DRY MATERIAL TO DISSIPATE
    THE POTENTIAL BUILDUP OF STATIC ELECTRICITY. (SUPP)

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR APPROVED RESPIRATORY PROTECTION,
    CHEMICALLY COMPATIBLE GLOVES & PROTECTIVE CLOTHING. WIPE UP/COLLECT
    LEAK USING A HIGH EFFICIENCY VACUUM CLEANER. AVOID BREATHING DUST.
    PLACE RELEASE IN APPROPRIAT ELY LABELLED CONTAINER FOR DISPOSAL.
    WASH SITE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN TIGHT CONTAINER. THIS
    MATERIAL SHOULD BE HANDLED & STORED PER LABEL INSTRUCTIONS TO
    ENSURE PRODUCT INTEGRITY.
Other Precautions:WHEN HANDLING, AVOID ALL CONTACT & INHALATION OF
    DUST, MISTS & VAPORS ASSOCIATED W/THE MATERIAL.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:USE A NIOSH APPROVED RESPIRATOR IF NECESSARY. IF
    RESPIRATOR IS UNAVAILABLE, AN APPROVED DUST MASK SHOULD BE USED.
Ventilation:RECOMMENDED
Protective Gloves:RUBBER
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:PROTECTIVE CLOTHING
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
AUTOIGNITION TEMP: 734F.

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:M.P/F.P Text:431.6-442F
Solubility in Water:SLIGHT
Appearance and Odor:WHITE TO SLIGHTLY YELLOW POWDER

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
ACIDS, BASES, OXIDIZING AGENTS
Stability Condition to Avoid:STATIC ELECTRICITY
Hazardous Decomposition Products:CHLORINE, NITROGEN OXIDIES, HYDROGEN
    CHLORIDE
Conditions to Avoid Polymerization:WHEN HEATED TO DECOMPOSITION,
    MATERIAL EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE W/LOCAL, STATE &
    FEDERAL REGULATIONS.

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 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
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 disclaims all liability for its use.  Any person utilizing this
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 particular situation.