PharmacyCodes

Nincaluicolflastine

Material Safety Data Sheet
Vinblastine sulfate, 96.0-102.0% (hplc)

ACC# 97987
Section 1 - Chemical Product and Company Identification

MSDS Name: Vinblastine sulfate, 96.0-102.0% (hplc)
Catalog Numbers: AC203450000, AC203450050, NC9164560, XXAC20345-1KG
Synonyms:
Company Identification:
              Fisher Scientific
              1 Reagent Lane
              Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
143-67-9 Vinblastine sulfate 96-102% 205-606-0

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: slightly yellow crystalline powder.
Danger! Harmful. Irritant. Hygroscopic (absorbs moisture from the air).
Target Organs: Heart, central nervous system, respiratory system, eyes, bone marrow, nervous system, skin.


Potential Health Effects
Eye: May cause irreversible eye injury.
Skin: Causes skin irritation.
Ingestion: Harmful if swallowed.
Inhalation: Causes respiratory tract irritation.
Chronic: May cause digestive tract disturbances.

Section 4 - First Aid Measures


Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid imme diately.
Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion: Get medical aid immediately. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, or carbon dioxide.
Flash Point: Not available.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: Not published.

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - Handling and Storage


Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage: Store in a tightly closed container. Store in a dry area. Keep refrigerated. (Store below 4�C/39�F.)

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Use adequate ventilation to keep airborne concentrations low.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Vinblastine sulfate none listed none listed none listed

OSHA Vacated PELs: Vinblastine sulfate: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Not available.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties


Physical State: Crystalline powder
Appearance: white - slightly yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:267 deg C
Decomposition Temperature:Not available.
Solubility: negligible in water
Specific Gravity/Density:Not available.
Molecular Formula:Not available.
Molecular Weight:909.05

Section 10 - Stability and Reactivity


Chemical Stability: Not available.
Conditions to Avoid: Incompatible materials, light, exposure to moist air or water.
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Carbon monoxide, oxides of nitrogen, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - Toxicological Information


RTECS#:      
CAS# 143-67-9: YY8400000
LD50/LC50:
CAS# 143-67-9:
     Oral, mouse: LD50 = 423 mg/kg;
     Oral, rat: LD50 = 305 mg/kg;
.

Carcinogenicity:
CAS# 143-67-9: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No information available.
Teratogenicity: No information available.
Reproductive Effects: ims-rat TDLo:125 �g/kg (female 8 days after conception)ipr-mus TDLo:350 �g/kg (female 9 days after conception)ipr-mus TDLo:250 �g/kg (female 9 days after conception)
Mutagenicity: dnr-esc 5 �g/platecyt-hmn:hla 10 �g/Lcyt-hmn:lym 3750 �g/Lmnt-rat:ipr 200 �g/kgdni-rat:ipt 1 mg/kgspm-rat:ipr 555 �g/kgmnt-mus:ipr 10 �g/kgEPA Genetox Program 1988, Negative: N crassa-aneuploidy
Neurotoxicity: No information available.
Other Studies:

Section 12 - Ecological Information

No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

US DOT Canada TDG
Shipping Name: ALKALOIDS, SOLID, N.O.S. No information available.
Hazard Class: 6.1
UN Number: UN1544
Packing Group: II

Section 15 - Regulatory Information

US FEDERAL
TSCA
     CAS# 143-67-9 is not listed on the TSCA inventory. It is for research and development use only.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 143-67-9 is not present on state lists from CA, PA, MN, MA, FL, or NJ.

California Prop 65
WARNING: This product contains Vinblastine sulfate, a chemical known to the state of California to cause developmental reproductive toxicity.
California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
     T
Risk Phrases:
     R 22 Harmful if swallowed.
     R 37/38 Irritating to respiratory system and skin.
     R 41 Risk of serious damage to eyes.
     R 61 May cause harm to the unborn child.

Safety Phrases:
     S 26 In case of contact with eyes, rinse immediately with plenty of
     water and seek medical advice.
     S 37/39 Wear suitable gloves and eye/face protection.
     S 45 In case of accident or if you feel unwell, seek medical advice
     immediately (show the label where possible).
     S 53 Avoid exposure - obtain special instructions before use.

WGK (Water Danger/Protection)
     CAS# 143-67-9: No information available.
Canada - DSL/NDSL
None of the chemicals in this product are listed on the DSL or NDSL list.
Canada - WHMIS
     WHMIS: Not available.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List

Section 16 - Additional Information

MSDS Creation Date: 9/02/1997
Revision #4 Date: 10/03/2005

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.