Metaclopramide

ROBINS A H CO INC -- AHR76470 METOCLOPRAMIDE INJECTABLE -- 6505-01-248-5399
=====================  Product Identification  =====================

Product ID:AHR76470 METOCLOPRAMIDE INJECTABLE
MSDS Date:09/08/1992
FSC:6505
NIIN:01-248-5399
MSDS Number: BWXVW
=== Responsible Party ===
Company Name:ROBINS A H CO INC
Address:1407 SHERWOOD AVE
Box:26609
City:RICHMOND
State:VA
ZIP:23261-6609
Country:US
Info Phone Num:804-257-2224/202-483-7616
Emergency Phone Num:804-257-2224/215-688-4400
CAGE:0DJZ0
=== Contractor Identification ===
Company Name:ROBINS A H CO INC
Address:2300 DARBYTOWN RD
Box:7672
City:RICHMOND
State:VA
ZIP:23231
Country:US
Phone:804-257-2000
CAGE:0DJZ0
Company Name:ROBINS, A.H. CO INC
Address:1407 SHERWOOD AVE
Box:26609
City:RICHMOND
State:VA
ZIP:23261-6609
Country:US
CAGE:04516

=============  Composition/Information on Ingredients  =============

Ingred Name:METOCLOPRAMIDE HYDROCHLORIDE
CAS:54143-57-6
Fraction by Wt: 0.6%

Ingred Name:WATER
CAS:7732-18-5
RTECS #:ZC0110000
Fraction by Wt: >1%

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50 (MOUSE): 280 MG/KG
Routes of Entry: Inhalation:NO	Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:SKIN: ABSORPTION MAY OCCUR. INGESTION:
    NARCOTIC/TOXIC, ANGIONEUROTIC EDEMA, EDEMA. MAY CROS PLACENTA & BE
    EXCRETED IN BREAST MILK. ALCOHOL MAY ENHANCE TOXIC EFFECTS. MAY
    IMPAIR PERFORMANCE OF TASKS RE QUIRING ALERTNESS. INTERACTIONS
    W/MEDICATIONS HAVE BEEN REPORTED.
Explanation of Carcinogenicity:NONE
Effects of
    Overexposure:DROWSINESS/DISORIENTATION/IRRITABILITY/AGITATION/MUSCL
    E HYPERTONIA/INVOLUNTARY MOVEMENT OF LIMBS/FACIAL
    GRIMACING/TORTICOLLIS/OCULOGYRIC CRISIS/RHYTHMIC PROTRUSION OF
    TONGUE/BULBAR TYPE OF SPEECH/TRIS
    MUS/OPISTHOTONUS/STRIDOR/DYSPNEA/LARYNGOSPASM/RESTLESSNESS/NERVOUSN
    ESS/SEDATION/SOMNOLENCE/FATIGUE/LASSITUDE (SEE SUPP)
Medical Cond Aggravated by Exposure:MENTAL DEPRESSION, EPILEPSY,
    HYPERTENSION, PHEOCHROMOCYTOMA, ASTHMA, RENAL IMPAIRMENT, BREAST
    CANCER, PARKINSON'S DISEASE, GI OBSTRUCTION/PERFORATION.

=======================  First Aid Measures  =======================

First Aid:INHALATION: REMOVE TO FRESH AIR. GIVE CPR IF NEEDED. KEEP
    WARM & QUIET. SKIN: WASH W/SOAP/MILD DETERGENT & LARGE AMOUNTS OF
    WATER FOR 15-20 MINS. EYES: IMMEDIATELY FLUSH W/LARGE AMOUNTS OF
    WATER/NORMA L SALINE FOR 15-20 MINS. INGESTION: IF VOMITING OCCURS,
    KEEP HEAD LOWER THAN HIPS TO PREVENT ASPIRATION. TREAT
    SYMPTOMATICALLY & SUPPORTIVELY. OBTAIN MEDICAL ATTENTION IN ALL
    CASES.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:USE MEDIA APPROPRIATE FOR SURROUNDING FIRE.
Fire Fighting Procedures:SAFELY MOVE CONTAINER FROM FIRE AREA. AVOID
    BREATHING VAPORS/DUSTS. KEEP UPWIND. WEAR SCBA W/FULL FACEPIECE
    OPERATED IN PRESSURE DEMAND/POSITIVE PRESSURE MODE.
Unusual Fire/Explosion Hazard:NEGLIGIBLE FIRE HAZARD WHEN EXPOSED TO
    HEAT/FLAME.

==================  Accidental Release Measures  ==================

Spill Release Procedures:SOAK UP W/VERMICULITE/OTHER ABSORBENT MATERIAL
    & PLACE INTO SUITABLE CONTAINERS FOR LATER DISPOSAL.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE AWAY FROM INCOMPATIBLE
    SUBSTANCES. AVOID REPEATED/PROLONGED CONTACT W/THIS SUBSTANCE.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR A NIOSH/MSHA APPROVED DUST & MIST
    RESSPIRATOR, SUPPLIED-AIR RESPIRATOR W/FULL FACEPIECE OPERATED IN A
    PRESSURE DEMAND/OTHER POSITIVE PRESSURE MODE IN COMBINATION
    W/AUXILIARY SCBA OPERATED IN PRES SURE DEMAND/POSITIVE PRESSURE
    MODE.
Ventilation:LOCAL EXHAUST/GENERAL DILUTION.
Protective Gloves:RECOMMENDED
Eye Protection:SPLASH-PROOF SAFETY GLASSES
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
    REUSE.
Supplemental Safety and Health
PH: 4.5-6.5. SYMPTOMS CONT'D:
    DYSTONIA/AKATHISIA/DIZZINESS/ANXIETY/INSOMNIA/HEADACHE/MYOCLONUS/TA
    RDIVE DUSKINESIA/MENTAL
    DEPRESSION/NAUSEA/DIARRHEA/URTICARIA/BRONCHOSPASM/VISUAL
    DISTURBANCES/HALLUCINA TIONS/CONVULSIVE SEIZURES/NIPPLE
    TENDERNESS/GYNECOMASTIA/NEUTROPENIA/LEUKOPENIA/AGRANULOCYTOSIS/PORP
    HYRIA.

==================  Physical/Chemical Properties  ==================

Boiling Pt:B.P. Text:212F
Vapor Pres:14
Spec Gravity:1
pH:(SUPP)
Solubility in Water:MISCIBLE
Appearance and Odor:CLEAR, COLORLESS, STERILE SOLUTIION.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
ACIDS, BASES, OXIDIZERS.
Stability Condition to Avoid:HEAT/FLAME.
Hazardous Decomposition Products:TOXIC &/HAZARDOUS GASES.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
    REGULATIONS.

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