Exocine

UNITED STATES PHARMACOPEIAL CONVENTION INC -- DEMECLOCYCLINE HYDROCHLORIDE -- 6505-00F036923
=====================  Product Identification  =====================

Product ID:DEMECLOCYCLINE HYDROCHLORIDE
MSDS Date:07/14/1988
FSC:6505
NIIN:00F036923
MSDS Number: BVSRC
=== Responsible Party ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Info Phone Num:301-881-0666
Emergency Phone Num:301-881-0666
Preparer's Name:WILLIAM M HELLER
CAGE:14128
=== Contractor Identification ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
Box:City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Phone:301-881-0666
CAGE:14128

=============  Composition/Information on Ingredients  =============

Ingred Name:DEMECLOCYCLINE HYDROCHLORIDE      *94-3*
CAS:64-73-3
RTECS #:QI7700000

Ingred Name:DEMECLOCYCLINE	 *94-3*
CAS:127-33-3
RTECS #:QI7650000

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50 (RAT): 2372 MG/KG
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:POSSIBLE ALLERGIC REACTIONS TO DUST IF
    INHALED/INGESTED/CONTACT W/SKIN. EYE/SKIN/RESPIRATORY TRACT
    IRRITATION. POSSIBLE HYPERSENSITIZATION. IRRITATION TO MUCOUS
    MEMBRANES & RESPSIRATORY TRACT. INDIVID UALS W/PREVIOUS HISTORY OF
    SIGNIFICANT ALLERGY TO ANTIBIOTICS/ASTHMA SHOULD AVOID POTENTIAL
    EXPOSURE TO THIS MATERIAL.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:POSSIBLE ALLERGIC REACTION TO DUST IF
    INHALED/INGESTED/CONTACT W/SKIN. EYE/SKIN/RESPIRATORY TRACT
    IRRITATION. POSSIBLE HYPERSENSITIZATION. IRRITATING TO MUCOUS
    MEMBRANES & RESPIRATORY TRACT. INDIVIDUA LS W/PREVIOUS HISTORY OF
    SIGNIFICANT ALLERGY TO ANTIBIOTICS/ASTHMA SHOULD AVOID POTENTIAL
    EXPSOSURE TO THIS MATERIAL.
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY TO MATERIAL

=======================  First Aid Measures  =======================

First Aid:INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NEEDED.
    EYES/SKIN: FLUSH W/COPIOUS AMOUNTS OF WATER. INGESTION: FLUSH MOUT
    OUT W/WATER. HYPERSENSITIVITY REACTIONS MUST RECEIVE IMMEDIATE
    MEDICAL AT TENTION. OBTAIN MEDICAL ATTENTION IN ALL CASES.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY, DRY CHEMICAL, CO2, FOAM AS APPROPRIATE
    FOR SURROUNDING FIRE/MATERIALS.
Fire Fighting Procedures:EVACUATE AREA. WEAR SELF CONTAINED BREATHING
    APPARATUS & PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:MATERIAL IS ASSUMED TO BE COMBUSTIBLE. AS
    W/ALL DRY POWDERS IT'S ADVISABLE TO GROUND MECHANICAL EQUIPMENT IN
    CONTACT W/DRY MATERIAL TO DISSIPATE STATIC.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR APPROVED RESPIRATOR & CHEMICALLY
    COMPATIBLE GLOVES. VACUUM/SWEEP UP. AVOID DUST. PLACE MATERIAL IN
    APPROPRIATE CONTAINER FOR WASTE DISPOSAL. VENTILATE AREA & WASH
    SITE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN TIGHT CONTAINER. SHOULD BE
    HANDLED/STORED PER LABEL/OTHER INSTRUCTIONS TO ENSURE PRODUCT
    INTEGRITY. USE W/ADEQUATE VENTILATION.
Other Precautions:AVOID CONTACT W/EYES, SKIN/CLOTHING. AVOID BREATHING
    DUST/MIST/FUMES/VAPORS. USE W/ADEAUATE DUST CONROL. DON'T PERMIT
    EATING/DRINKING/SMOKING NEAR MATERIAL.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR NIOSH APPROVED RESPIRATOR.
Ventilation:ADEQUATE. LOCAL EXHAUST/MECHANICAL (GENERAL): RECOMMENDED.
Protective Gloves:RUBBER, VINYL
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:APPROPRIATE LABORATORY APPAREL
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
    REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
INDIVIDUALS WORKING W/CHEMICALS SHOULD CONSIDER ALL CHEMICALS TO BE
    POTENTIALLY HAZARDOUS EVEN IF THEIR INDIVIDUAL HAZARDS MAY BE
    UNCHARACTERIZED/UNKNOWN.

==================  Physical/Chemical Properties  ==================

Solubility in Water:SLIGHT
Appearance and Odor:YELLOW CRYSTALLINE POWDER W/NO ODOR

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:TOXIC FUMES

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
    REGULATIONS.

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.