Dihydroxyphosphinecarboxylic acid oxide

ASTRA PHARMACEUTICAL PRODUCTS INC -- FOSCAVIR/FOSCARNET SODIUM INJECTION -- 6505-01-355-7374
=====================  Product Identification  =====================

Product ID:FOSCAVIR/FOSCARNET SODIUM INJECTION
MSDS Date:10/05/1991
FSC:6505
NIIN:01-355-7374
MSDS Number: BZGCH
=== Responsible Party ===
Company Name:ASTRA PHARMACEUTICAL PRODUCTS INC
Address:50 OTIS ST
City:WESTBOROUGH
State:MA
ZIP:01581-3323
Country:US
Info Phone Num:508-366-1100/800-225-6333
Emergency Phone Num:800-225-6333/508-366-1100
CAGE:04473
=== Contractor Identification ===
Company Name:ASTRA PHARMACEUTICAL PRODUCTS INC
Address:50 OTIS ST
Box:City:WESTBOROUGH
State:MA
ZIP:01581-3323
Country:US
Phone:508-366-1100/800-225-6333
CAGE:04473

=============  Composition/Information on Ingredients  =============

Ingred Name:FOSCARNET SODIUM (DIHYDROXYPHOSPHINECARBOXYLIC ACID OXIDE
    TRISODIUM SALT)  *96-1*
CAS:63585-09-1
RTECS #:SY8200000
Fraction by Wt: 2.4%

Ingred Name:HYDROCHLORIC ACID, HYDROGEN CHLORIDE, MURIATIC ACID        
    HYDROCHLORIDE
CAS:7647-01-0
RTECS #:MW4025000
Fraction by Wt: <1%
Other REC Limits:7 PPM
OSHA PEL:5 PPM
ACGIH TLV:C 11 MG/CUM
EPA Rpt Qty:5000 LBS
DOT Rpt Qty:5000 LBS

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50(RATS): >2000 MG/KG
Routes of Entry: Inhalation:NO	Skin:NO  Ingestion:NO
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:FOSCARNET SODIUM SOLUTION HAS A LOW
    ACUTE TOXICITY. IT HAS BEEN FOUND TO BIND TO BONE MATRIX. CONTACT
    W/SKIN & EYES MAY CAUSE SLIGHT IRRITATION. FOSCARNET SODIUM HAS
    BEEN ASSOCIATED OF KIDNEY IMPAIRME NT, THROMBOPHLEBITIS & DECREASES
    IN HEMOGLOBIN LEVELS IN CLINICAL PATIENTS.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:REDNESS, TEARING, IRRITATION

=======================  First Aid Measures  =======================

First Aid:FLUSH EYES & SKIN W/COPIOUS AMOUNTS OF CLEAR WATER FOR 15
    MINS. OBTAIN MEDICAL ATTENTION IN ALL CASES.

=====================  Fire Fighting Measures  =====================

Flash Point:NON-FLAMMABLE
Extinguishing Media:WATER, DRY CHEMICAL, CO2/FOAM AS APPROPRIATE FOR
    ADJACENT MATERIALS
Fire Fighting Procedures:NONE
Unusual Fire/Explosion Hazard:AT HIGH TEMPS, POWDER CAN EMIT TOXIC
    FUMES; THIS HAZARD IS NEGLIGIBLE W/RESPECT TO FOSCARNET SODIUM
    SOLUTION.

==================  Accidental Release Measures  ==================

Spill Release Procedures:ABSORB W/INERT MATERIALS.

======================	Handling and Storage  ======================

Handling and Storage Precautions:AVOID SHIPPING/STORING AT TEMPS
    <47F/FOSCARNET SODIUM WILL PRECIPITATE DUE TO REDUCED SOLUBILITY.
    KEEP IN ORIGINAL, SEALED CONTAINERS.
Other Precautions:MATERIAL SHOULD BE LABELED AS AN IRRITANT & A TOXIC
    CHEMICAL. AVOID INGESTION & PROLONGED CONTACT W/SKIN & EYES.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:NONE
Ventilation:LOCAL EXHAUST
Protective Gloves:RECOMMENDED
Eye Protection:SAFETY GLASSES RECOMMENDED
Other Protective Equipment:NONE
Supplemental Safety and Health
FOSCARNET SODIUM IS A RELATIVELY NON-TOXIC VIRASTATIC AGENT THAT'S NOT
    METABOLIZED & IS RAPIDLY EXCRETED IN URINE. THIS SUBSTANCE IS
    SLIGHTLY ABSORBED THROUGH INTACT SKIN WHEN APPLICED PERCUTANEOUSLY.
     ALTHOUGH FOSCARNET SODIUM CAN BIND TO BONE MATRIX, IT HAS BEEN
    SHOWN TO AFFECT VITAMIN D METABOLISM.

==================  Physical/Chemical Properties  ==================

Boiling Pt:B.P. Text:212F
Melt/Freeze Pt:M.P/F.P Text:32F
Vapor Pres:17
Vapor Density:0.6
Spec Gravity:1
Evaporation Rate & Reference:(WATER=1): 1
Solubility in Water:COMPLETE
Appearance and Odor:CLEAR & COLORLESS LIQUID

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
NONE
Stability Condition to Avoid:NONE
Hazardous Decomposition Products:HIGH TEMPS: TOXIC FUMES

====================  Disposal Considerations  ====================

Waste Disposal Methods:INCINERATE/DISPOSE OF IN ACCORDANCE W/LOCAL,
    STATE & FEDERAL REGULATIONS.

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