Dihydroxyanthraquinone

AMERICAN CYANAMID CO LEDERLE LABORATORIES DIV -- NOVANTRONE MITOXANTRONE HCL CONCENTRATE FOR INJECTION,9393 -- 6505-01-292-6658
=====================  Product Identification  =====================

Product ID:NOVANTRONE MITOXANTRONE HCL CONCENTRATE FOR INJECTION,9393
MSDS Date:04/09/1991
FSC:6505
NIIN:01-292-6658
MSDS Number: BSHPC
=== Responsible Party ===
Company Name:AMERICAN CYANAMID CO LEDERLE LABORATORIES DIV
Address:1 CYANAMID PLZ
City:WAYNE (FORMALLY IN PEARL RIVER,NY,10965)
State:NJ
ZIP:07470
Country:US
Info Phone Num:201-831-2000
Emergency Phone Num:201-831-2000
Preparer's Name:CHARLES S. SCHWARTZ, PHD
CAGE:06404
=== Contractor Identification ===
Company Name:AMERICAN CYANAMID CO LEDERLE LABORATORIES DIV
Address:1 CAMPUS DR
Box:City:PARSIPPANY
State:NJ
ZIP:07054-4404
Country:US
Phone:973-683-2000
CAGE:06404
Company Name:AMERICAN CYANAMID CO LEDERLE LABORATORIES DIV
Address:1 CYANAMID PLZ
Box:City:WAYNE
State:NJ
ZIP:07470
Country:US
Phone:201-831-2000
CAGE:3M726

=============  Composition/Information on Ingredients  =============

Ingred Name:MITOXANTRONE HCL
CAS:70476-82-3
Fraction by Wt: 0.2%
Other REC Limits:NONE RECOMMENDED

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50 (RAT): 682-721 MG/KG
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:NO
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:INHALATION-MILDLY IRRITATING.
    INGESTION-MAY CAUSE GI IRRITATION. SKIN-MAY CAUSE IRRITATION.
    EYE-IRRITATION. CHRONIC:CARDIOVASCULAR AND BIRTH DEFECTS.
    CYTOTOXIC.
Effects of Overexposure:IRRITAION, REDNESS, NAUSEA, VOMITING, LOOSE
    STOOL, DIARRHEA, DECREASE WHITE BLOOD CELL COUNT, INCREASED
    SUSCEPTIBILITY TO INFECTION.
Medical Cond Aggravated by Exposure:NONE KNOWN.

=======================  First Aid Measures  =======================

First Aid:EYE-FLUSH PROMPTLY WITH PLENTY OF WATER FOR AT LEAST 15
    MINUTES. SKIN-WASH WITH SOAP & WATER; THEN FLUSH WITH WATER UNTIL
    CHEMICAL IS REMOVED. INGESTION-IF CONSCIOUS, INDUCE VOMITING AS
    DIRECTED BY DO CTOR, IMMEDIATELY GET MEDICAL HELP.
    INHALATION-REMOVE TO FRESH AIR. IF BREATHING IS DIFFICULT, GIVE
    OXYGEN. GET MEDICAL ATTENTION IF SYMPTOMS PERSIST.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:USE WATER FOG, CARBON DIOXIDE, FOAM, OR DRY
    CHEMICAL.
Fire Fighting Procedures:WEAR FIRE FIGHTING PROTECTIVE EQUIPMENT AND A
    FULL FACED SELF CONTAINED BREATHING APPARATUS. COOL FIRE EXPOSED
    CONTAINERS WITH WATER SPRAY.
Unusual Fire/Explosion Hazard:COMBUSTION OR HEAT OF FIRE MAY PRODUCE
    HAZARDOUS DECOMPOSITION PRODUCTS AND VAPORS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR PROTECTIVE EQUIPMENT. WIPE OR MOP UP AND
    PLACE IN A CONTAINER FOR DISPOSAL. FLUSH RESIDUE AWAY WITH WATER.
Neutralizing Agent:WATER PLUS DISH SOAP

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE AT 59-86F. DO NOT REFRIGERATE OR
    FREEZE. SHELF LIFE FROM DATE OF MFRG IS 2 YRS. PROTECT FROM
    PHYSICAL DAMAGE.
Other Precautions:NOVANTRONE CONCENTRATE IS FOR INJECTION ONLY. KEEP
    OUT OF REACH OF CHILDREN. FOR THERAPEUTIC USE ONLY.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:NONE NORMALLY REQUIRED. USE NIOSH APPROVED
    SELF-CONTAINED BREATHING APPARATUS IF TLV IS EXCEEDED OR WHEN USING
    IN CONFINED SPACES.
Ventilation:LOCAL TO CONTROL DUST OR MIST.
Protective Gloves:RUBBER
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:WEAR REGULAR WORK CLOTHES, INCLUDING
    LONG-SLEEVED SHIRT & TROUSERS.
Work Hygienic Practices:WASH HANDS, FACE AND EXPOSED BODY PART AT LUNCH
    & BREAKS, AND AT END OF SHIFT.
Supplemental Safety and Health
THIS MEDICINE IS USED AS AN ANTICANCER, OCCUPATIONAL HAZARD IS
    INVOLVED. TAKE PRECAUTIONS AGAINST OVEREXPOSURE. TOXIC CHLORINE GAS
    IS GENERATED WHEN MIXED WITH BLEACH.

==================  Physical/Chemical Properties  ==================

HCC:N1
Boiling Pt:B.P. Text:212F,100C
pH:3-4.5
Appearance and Odor:STERILE, DARK BLUE SOLUTION, ODORLESS.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
OXIDIZING AGENTS, LIKE HYPOCHLORITE AND PERMANGANATE.
Stability Condition to Avoid:HIGH HEAT.
Hazardous Decomposition Products:TOXIC OXIDES OF CARBON AND NITROGEN,
    ALDEHYDES, KETONES, ORGANIC ACIDS, POSSIBLY HYDROGEN CYANIDE &
    HYDROGEN CHLORIDE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE WITH APPLICABLE LOCAL,
    STATE AND FEDERAL REGULATIONS.

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 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.