Dihydroergotamine methanesulfonate

UNITED STATES PHARMACOPEIAL CONVENTION INC -- DIHYDROERGOTAMINE MESYLATE -- 6505-00F036918
=====================  Product Identification  =====================

Product ID:DIHYDROERGOTAMINE MESYLATE
MSDS Date:02/02/1989
FSC:6505
NIIN:00F036918
MSDS Number: BVSQW
=== Responsible Party ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Info Phone Num:301-881-0666
Emergency Phone Num:301-881-0666
Preparer's Name:WILLIAM M HELLER
CAGE:14128
=== Contractor Identification ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
Box:City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Phone:301-881-0666
CAGE:14128

=============  Composition/Information on Ingredients  =============

Ingred Name:MESYLATE	   *94-3*
CAS:6190-39-2
RTECS #:KE7920000

Ingred Name:DIHYDROERGOTAMINE	  *94-3*
CAS:511-12-6
RTECS #:II3675000

=====================  Hazards Identification  =====================

Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:POSSIBLE ALLERGIC REACTION TO DUST IF
    INHALED/INGESTED/CONTACT W/SKIN. EYE/SKIN/RESPIRATORY TRACT
    IRRITATION. POSSIBLE HYPERSENSITIZATION. IRRITATING TO MUCOUS
    MEMBRANES & RESPIRATORY TRACT. DON'T USE  DURING PREGNANCY. MAY BE
    HYPERSENSITIVE TO THIS MATERIAL IF HYPERSENSITIVE TO OTHER ERGOT
    DERIVATIVES.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:IRRITATION, NAUSEA, VOMITING, HEADACHE,
    DIARRHEA, THIRST, COLDNESS OF SKIN, PRURITUS, WEAK PULSE, NUMBNESS,
    TINGLING OF EXTREMITIES, CONFUSION.
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY TO MATERIAL,
    CORONARY ARTERY DISEASE, RENAL IMPAIRMENT

=======================  First Aid Measures  =======================

First Aid:INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NEEDED.
    EYES/SKIN: FLUSH W/COPIOUS QUANTITIES OF WATER. INGESTION: FLUSH
    OUT MOUTH W/WATER. TREATMENT OF ACUTE POISONING IS SYMPTOMATIC.
    EMPTY STOMA CH BY ASPIRATION/LAVAGE. AMYL NITRATE INHALATIONS
    HELPFUL. CONTROL NAUSEA/VOMITING BY INTRAMUSCULAR INJECTION OF
    25-50MG CHLOROPROMAZINE/COMPARABLE DOSE OF RELATED PHENOTHIAZINE.
    (SUPP)

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY, DRY CHEMICAL, CO2, FOAM AS APPROPRIATE
    FOR SURROUNDING FIRE/MATERIALS.
Fire Fighting Procedures:EVACUATE AREA. WEAR SELF CONTAINED BREATHING
    APPARATUS & PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:MATERIAL IS ASSUMED TO BE COMBUSTIBLE. AS
    W/ALL DRY POWDERS IT'S ADVISABLE TO GROUND MECHANICAL EQUIPMENT IN
    CONTACT W/DRY MATERIAL TO DISSIPATE STATIC.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR APPROVED RESPIRATOR & CHEMICALLY
    COMPATIBLE GLOVES. VACUUM/SWEEP UP. AVOID DUST. PLACE MATERIAL IN
    APPROPRIATE CONTAINER FOR WASTE DISPOSAL. VENTILATE AREA & WASH
    SITE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN TIGHT CONTAINER. SHOULD BE
    HANDLED/STORED PER LABEL/OTHER INSTRUCTIONS TO ENSURE PRODUCT
    INTEGRITY. USE W/ADEQUATE VENTILATION.
Other Precautions:AVOID CONTACT W/EYES, SKIN/CLOTHING. AVOID BREATHING
    DUST/MIST/FUMES/VAPORS. USE W/ADEQUATE DUST CONROL. DON'T PERMIT
    EATING/DRINKING/SMOKING NEAR MATERIAL.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR NIOSH APPROVED RESPIRATOR.
Ventilation:ADEQUATE. LOCAL EXHAUST/MECHANICAL (GENERAL): RECOMMENDED.
Protective Gloves:RUBBER
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:APPROPRIATE LABORATORY APPAREL
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
    REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
INDIVIDUALS WORKING W/CHEMICALS SHOULD CONSIDER ALL CHEMICALS TO BE
    POTENTIALLY HAZARDOUS EVEN IF THEIR INDIVIDUAL HAZARDS MAY BE
    UNCHARACTERIZED/UNKNOWN. FIRST AID CONT'D: HYPERSENSITIVITY
    REACTIONS  MUST RECEIVE IMMEDIATE MEDICAL ATTENTION. OBTAIN MEDICAL
    ATTENTION IN ALL CASES.

==================  Physical/Chemical Properties  ==================

Solubility in Water:SLIGHT
Appearance and Odor:WHITE TO SLIGHTLY YELLOWISH POWDER/OFF-WHITE TO
    FAINTLY RED POWDER W/FAINT ODOR

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:HEAT
Hazardous Decomposition Products:TOXIC FUMES, SULFUR OXIDES, NITROGEN
    OXIDES.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
    REGULATIONS.

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.