Chloroethylcyclohexylnitrosourea

BRISTOL MYERS SQUIBB CO -- CEENU 10 MG/CAPSULE -- 6505-01-087-6164
=====================  Product Identification  =====================

Product ID:CEENU 10 MG/CAPSULE
MSDS Date:03/01/1990
FSC:6505
NIIN:01-087-6164
MSDS Number: BNTQG
=== Responsible Party ===
Company Name:BRISTOL MYERS SQUIBB CO
Address:2400 W LLYOD EXPY
City:EVANSVILLE
State:IN
ZIP:47721
Country:US
Info Phone Num:812-429-5678; 812-429-5644
Emergency Phone Num:812-429-5000
Preparer's Name:MEDICAL SERVICES
CAGE:IO660
=== Contractor Identification ===
Company Name:BRISTOL MYERS SQUIBB
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Phone:201-519-2885
CAGE:IO660
Company Name:BRISTOL-MYERS US PHARMACEUTICAL & NUTRITIONAL GP.
Address:2400 W LLOYD EXPY
Box:City:EVANSVILLE
State:IN
ZIP:47721-0001
Country:US
Phone:812-429-5644
CAGE:29398

=============  Composition/Information on Ingredients  =============

Ingred Name:UREA, 1-(2-CHLOROETHYL)-3-CYCLOHEXYL-1-NITROSO-; (CCNU).
    LD50: (ORAL, RAT) 70 MG/KG.
CAS:13010-47-4
RTECS #:YS4900000
Fraction by Wt: 4.5%

Ingred Name:SUPP DATA: STAFF MEMBERS WHO ARE PREGNANT, ARE
    BREASTFEEDING, OR WHO ARE CONCERNED W/OTHER REPROD ISSUES SHLD BE
    (ING 3)
RTECS #:9999999ZZ

Ingred Name:ING 2: ENCOURAGED TO CONSULT W/THE OCCUP HLTH MD MONITORING
    WORKERS' HLTH. FEDERAL LAW PROHIBITS DISPENSING (ING 4)
RTECS #:9999999ZZ

Ingred Name:ING 3: WITHOUT PRESCRIPTION. SEE PACKAGE INSERT FOR
    RECOMMENDED MEDICAL USE.
RTECS #:9999999ZZ

Ingred Name:HYGIENE PRACT: PREPARATION AREA SHOULD BE FORBIDDEN.
RTECS #:9999999ZZ

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:SEE INGREDIENT 1
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:YES    IARC:YES	  OSHA:NO
Health Hazards Acute and Chronic:ACUTE: INGEST: CYTOTOXIC AGENT.
    IMPORTANT DOSE-DEPENDENT EFFECTS INCLUDE: HEMOTOLOGIC, HEPATIC,
    LUNG & KIDNEY TOXICITY. INHAL: UNKNOWN. SKIN: MAY BE ABSORBED THRU
    SKIN. POSSIBLE RASH UPON CONTACT. EYE  CONTACT: MAY CAUSE
    CONJUNCTIVITIS. CHRONIC: POTENTIAL CARCINOGEN.
Explanation of Carcinogenicity:CCNU: GROUP 2 (NTP), GROUP 2A (IARC).
Effects of Overexposure:SEE HEALTH HAZARD.
Medical Cond Aggravated by Exposure:NONE SPECIFIED BY MANUFACTURER.

=======================  First Aid Measures  =======================

First Aid:EYES: WASH WITH COPIOUS AMOUNTS OF WATER FOR A MINIMUM OF 15
    MINUTES AND IMMEDIATELY SEEK MEDICAL ATTENTION. SKIN: WASH AFFECTED
    AREA IMMEDIATELY WITH SOAP & WATER. INGEST/INHAL: SEEK PROFESSIONAL
    MED ICAL ATTENTION IF APPROPRIATE.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:CO*2, DRY CHEMICAL.
Fire Fighting Procedures:WEAR NIOSH/MSHA APPROVED SCBA & FULL
    PROTECTIVE EQUIPMENT .
Unusual Fire/Explosion Hazard:UNKNOWN. DOES NOT SUPPORT COMBUSTION.

==================  Accidental Release Measures  ==================

Spill Release Procedures:PICK UP INTACT CAPSULES. IF CAPSULES ARE
    CRUSHED, WIPE SOLID WITH WET ABSORBENT GAUZE OR TOWELS.
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

======================	Handling and Storage  ======================

Handling and Storage Precautions:AVOID EXCESSIVE HEAT (OVER 40C). STORE
    AT ROOM TEMPERATURE. SEE OSHA INSTRUCTION PUB 8-1.1 FOR ADDL WORK
    PRACTICE QUIDELINES FOR HANDLING THIS MATL.
Other Precautions:PRE-PLACEMENT PHYSICAL EXAM & HISTORY (NOTING ANY
    RISK FACTORS) FOR EMPLOYEES W/POTNTL EXPOS TO CEENU IS RECOMMENDED.
    A COMPLETE BLOOD COUNT, INCL DIFFERENTIAL, MAY BE TAKEN TO PROVIDE
    A BASELINE. PER IODIC FOLLOW-UP EXAMINATIONS (SUPP DATA)

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:RESPIRATORY PROTECTION WITH NIOSH/MSHA APPRVD
    DUST RESPIRATOR, HIGH EFFICIENCY DUST FILTER OR POWERED
    AIR-PURIFYING RESPIRATOR IF BSC OR SUITABLE VENTILATION IS NOT
    AVAILABLE AND A NUMBER OF CAPSULES	ARE TO BE OPENED.
Ventilation:BIOLOGICAL SAFETY CABINET OR LABORATORY EXHAUST HOOD IF
    CAPSULES ARE TO BE OPENED.
Protective Gloves:DISPOSABLE LATEX GLOVES.
Eye Protection:CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:PROT DISPOSABLE GOWN OF LOW PERMEABILITY
    FABRIC W/CLOSED FRONT, LONG SLEEVES/ELASTIC CUFFS IF CAPSULES ARE
    TO BE OPENED.
Work Hygienic Practices:WASH THORO BEFORE EATING/SMKG. EATING/DRINKING/
    SMKG/CHEWING GUM/APPLYING COSMETICS OR STORING FOOD NEAR (ING 5)
Supplemental Safety and Health
CNDTNS (STAB): AVOID EXCESSIVE HEAT (OVER 40C). OTHER PREC: SHLD BE
    GIVEN I/A/W INSTITUTIONAL POLICY, OVERSEEN BY MD THORO
    KNOWLEDGEABLE ABOUT BOTH THE TOXICITY OF THE SUBSTANCE AND THE
    EXTENT OF WORK PLACE EXPOSURE. A PERMANENT REGISTRY OFALL STAFF WHO
    ROUTINELY PREPARE OR ADMINISTER CEENU SHLD BE CONSIDERED. (ING 2)

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:M.P/F.P Text:194F,90C
Solubility in Water:INSOLUBLE
Appearance and Odor:YELLOW POWDER IN CAPSULES.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
NO KNOWN HAZARDOUS INCOMPATIBILITIES.
Stability Condition to Avoid:WHEN STORED AT ROOM TEMP IN ORIGINAL
    CONTR, CMPD IS STABLE TO EXPIRATION DATE INDICATED ON LABEL OF
    PROD. (SUPP DATA)
Hazardous Decomposition Products:UNKNOWN, BUT ASSUME A CARCINOGENIC
    POTENTIAL.

====================  Disposal Considerations  ====================

Waste Disposal Methods:TREAT PRODUCT AND CONTAMINATED MATERIALS AS
    HAZARDOUS WASTE. INCINERATION IS RECOMMENDED. DISPOSAL MUST BE IN
    ACCORDANCE WITH FEDERAL, STATE, AND LOCAL REGULATIONS .

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