Cefuroxime

GLAXO INC -- CEFUROXIME SODIUM -- 6505-01-209-1205
=====================  Product Identification  =====================

Product ID:CEFUROXIME SODIUM
MSDS Date:11/12/1990
FSC:6505
NIIN:01-209-1205
MSDS Number: BWMHG
=== Responsible Party ===
Company Name:GLAXO INC
Address:5 MOORE DR
City:RESEARCH TRIANGLE PARK
State:NC
ZIP:27709
Country:US
Info Phone Num:919-248-2354
Emergency Phone Num:919-248-2100/2700
Preparer's Name:DIRECTOR, ENVIRON SAFETY
CAGE:34006
=== Contractor Identification ===
Company Name:GLAXO WELLCOME INC.
Address:5 MOORE DR
Box:13398
City:DURHAM
State:NC
ZIP:27709
Country:US
Phone:919-248-2100
CAGE:34006

=============  Composition/Information on Ingredients  =============

Ingred Name:CEFUROXIME SODIUM
CAS:56238-63-2
RTECS #:XI0330000
Fraction by Wt: 100%
Other REC Limits:0.1 MG/M3 (MFR)

=====================  Hazards Identification  =====================

Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ZINACEF IS A CEPHALOSPORIN ANTIBIOTIC
    USED TO TREAT BACTERIAL INGECTIONS DUE TO SUSCEPTIBLE ORGANISMS.
    ACUTE DUST EXPOSURE MAY CAUSE MILD TO SEVERE ALLERGIC REACTIONS IN
    SENSITIVE INDIVIDUALS. THERE I S NO RECORDED FATAL ANAPHYLAXIS, BUT
    ITIS A POSSIBILITY. MAY BE A SKIN SENSITIZER.
Explanation of Carcinogenicity:THERE IS NO PUBLISHED EVIDENCE THAT THE
    COMPOUND IS CARCINOGENIC OR TERATOGENIC. WAS NEGATIVE ON THE
    MUTAGENIC AMES TEST
Effects of Overexposure:INHALED:RESPIRATORY IRRITATION,ITCHY SKIN
    RASHES,HIVES,RUNNY/STUFFY NOSE,CHEST TIGHTNESS,SWELLING & DIFFICULT
    BREATHING. SKIN:SENSITIZER. RED ITCHY SKIN RASH AFTER REPEATED
    CONTACT.
Medical Cond Aggravated by Exposure:ALLERGIC REACTIONS MAY OCCUR IN
    INDIVIDUALS SENSITIVE TO CEPHALOSPORINS, PENICILLLINS OR RELATED
    COMPOUNDS.

=======================  First Aid Measures  =======================

First Aid:EYE:FLUSH THOROUGHLY W/LARGE AMOUNT OF WATER. GET MEDICAL
    ATTENTION. SKIN:REMOVE CONTAMINATED CLOTHING & WASH W/SOAP & WATER.
    INHALED:REMOVE VICTIM TO FRESH AIR. IF BREATHING IS DIFFICULT OR
    CEASES, G IVE OXYGEN OR CPR. GET MEDICAL ATTENTION. INGESTED:RINSE
    MOUTH WITH WATER. GET MEDICAL ATTENTION.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY, FOAM, MULTI-PURPOSE DRY CHEMICAL.
Fire Fighting Procedures:WEAR FULL PROTECTIVE CLOTHING AND USE SELF
    CONTAINED BREATHING APPARATUS.
Unusual Fire/Explosion Hazard:AS WITH ANY ORGANIC DUST, THERE IS
    POTENTIAL FOR EXPLOSION WHEN SUSPENDED IN AIR IN HIGH
    CONCENTRATIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR FULL PROTECTIVE EQUIPMENT. AVOID BODY
    CONTACT AND/OR BREATHING DUST. COLLECT SPILLAGE BY CAREFULLLY
    SWEEPING OR VACUUMING WITH HEPA FILTEREDVACUUM & PLACE IN LABELED,
    SEALED CONTAINER FOR REUSE O R DISPOSAL. WASH AREA AFTER VACUUMING.
Neutralizing Agent:MFR GAVE NO INFORMATION ON MSDS.

======================	Handling and Storage  ======================

Handling and Storage Precautions:USE STORAGE PRACTICES THAT WILL
    MINIMIZE GENERATION OF DUST.
Other Precautions:SPECIAL CARE SHOULD BE TAKEN TO INSURE THAT
    CONTAMINATED CLOTHING & EQUIPMENT ARE PROPERLY CLEANED AFTER USE.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR RESPIRATORY PROTECTIVE EQUIPMENT WHEN
    EXPOSED TO DUST LEVELS THAT EXCEED THE ESTIMATED SAGE WORKING LEVEL
    (MFR'S). FOLLOW NIOSH, ANSI Z88.2, AND THE RESPIRATORY EQUIPMENT
    MANUFACTURER'S RECOMMEND ATIONS.
Ventilation:PROVIDE LOCAL EXHAUST VENTILATION SYSTEM AT THE SOURCE OF
    DUST GENERATION.
Protective Gloves:WEAR PROTECTIVE GLOVES AT ALL TIMES.
Eye Protection:PROTECT EYE FROM DUST.
Other Protective Equipment:A PROTECTIVE OUTER GARMENT IS ADEQUATE FOR
    LOW DUST EXPOSURE. FOR HIGH EXPOSURE, WEAR WEAR FULL BODY
    PROTECTION.
Work Hygienic Practices:ALL SKIN CONTACT SHOULD BE AVOIDED. EMPLOYEES
    EXPOSED TO DUST SHOULD CHANGE CLOTHES & SHOWER AT END OF WORK
    ASSIGNMENT.
Supplemental Safety and Health
NONE

==================  Physical/Chemical Properties  ==================

HCC:N1
NRC/State Lic Num:NONE
Melt/Freeze Pt:M.P/F.P Text:420F,216C
Solubility in Water:15% W/V
Appearance and Odor:WHITE TO CREAMY WHITE POWDER, ODOR NOT LISTED

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
NO KNOWN INCOMPATIBILITIES.
Stability Condition to Avoid:SLIGHTLY UNSTABLE IN AIR & WILL SLOWLY
    DECOMPOSE. THE MATERIAL SHOULD BE PROTECTED FROM LIGHT AND STORED
    UNDER NITROGEN.
Hazardous Decomposition Products:THERMAL DECOMPOSITION PRODUCTS INCLUDE
    TOXIC & CORROSIVE OXIDES OF NITROGEN AND SULFUR.

====================  Disposal Considerations  ====================

Waste Disposal Methods:INCINERATE AT AN APPROVED FACILITY I/A/W
    FEDERAL, STATE & LOCAL REGULATIONS.

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.