Butorphanol Tartrate

BRISTOL-MEYERS SQUIBB, PHARMACEUTICAL GROUP -- STADOL NASAL SPRAY (10 MG/ML) -- 6505-01-371-8384
=====================  Product Identification  =====================

Product ID:STADOL NASAL SPRAY (10 MG/ML)
MSDS Date:03/27/1992
FSC:6505
NIIN:01-371-8384
MSDS Number: BWZNX
=== Responsible Party ===
Company Name:BRISTOL-MEYERS SQUIBB, PHARMACEUTICAL GROUP
Address:600 COLLEGE RD
City:PRINCETON
State:NJ
ZIP:08543-4500
Country:US
Info Phone Num:609-243-6000
Emergency Phone Num:908-519-2385(CHEMTREC 800-424-9300)
CAGE:0NWX1
=== Contractor Identification ===
Company Name:BRISTOL-MEYERS SQUIBB PHARMACEUTICAL
Address:600 COLLEGE RD E
Box:4500
City:PRINCETON
State:NJ
ZIP:08543
Country:US
Phone:609-243-6102
CAGE:0NWX1
Company Name:BRISTOL-MYERS SQUIBB PHARMACEUTICAL CO APOTHECON
Address:600 COLLEGE RD E
Box:4500
City:PRINCETON
State:NJ
ZIP:08543-4500
Country:US
Phone:609-243-6000
CAGE:0MN35

=============  Composition/Information on Ingredients  =============

Ingred Name:BUTORPHANOL TARTRATE (ALT. CAS#S- 54244-71-2; 5496-23-0;
    61005-22-9)
CAS:58786-99-5
RTECS #:QC7795000
Fraction by Wt: 1%
Other REC Limits:NONE RECOMMENDED

Ingred Name:WATER
CAS:7732-18-5
RTECS #:ZC0110000
Fraction by Wt: >1%
Other REC Limits:NONE RECOMMENDED

Ingred Name:BENZETHONIUM CHLORIDE
CAS:121-54-0
RTECS #:BO7180000
Fraction by Wt: <1%
Other REC Limits:NONE RECOMMENDED

Ingred Name:CITRIC ACID
CAS:77-92-9
RTECS #:GE7350000
Fraction by Wt: <1%
Other REC Limits:NONE RECOMMENDED

Ingred Name:SODIUM CHLORIDE
CAS:7647-14-5
RTECS #:VZ4725000
Fraction by Wt: <1%
Other REC Limits:NONE RECOMMENDED

Ingred Name:SODIUM HYDROXIDE (CERCLA)
CAS:1310-73-2
RTECS #:WB4900000
Fraction by Wt: <1%
Other REC Limits:NONE RECOMMENDED
OSHA PEL:2 MG/M3
ACGIH TLV:C 2 MG/M3; 9495
EPA Rpt Qty:1000 LBS
DOT Rpt Qty:1000 LBS

=====================  Hazards Identification  =====================

Routes of Entry: Inhalation:NO	Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ACUTE:NOT NORMALLY AN INHALATION
    HAZARD;BUT MAY PRODUCE SYMPTOMS SIMILAR TO INGESTION.NO INFORMATION
    AVAILABLE ON DERMAL TOXICITY.INGESTESTION MAY CAUSE CNS EFFECTS,GI
    TRACT EFFECTS,CARDIOVASCULAR EFF ECTS,DERMATOLOGIC
    EFFECTS,RESPIRATORY DEPRESSION.CHRONIC:PROLONGED EXPOSURE MAY LEAD
    PHYSICAL/PHSYCOLOGICAL DEPENDENCE.
Explanation of Carcinogenicity:NO INGREDIENT OF A CONCENTRATION OF 0.1%
    OR GREATER IS LISTED AS A CARCINOGEN OR SUEPECTED CARCINOGEN.
Effects of Overexposure:SEDATION, NAUSEA, CLAMMINESS, SWEATINESS,
    HEADACHE, VERTIGO, DIZZINESS, LETHARGY, CONFUSION, LIGHTHEADEDNESS,
    NERVOUSNESS, EUPHORIA, HALLUCINATIONS, INSOMNIA, PALPITATIONS,
    BRADICARDIA, ABDOMINAL CRAM PS, CONSTIPATION, VOMITING, RASH,
    ITCHING.
Medical Cond Aggravated by Exposure:PHYSICAL DEPENDENCE ON NARCOTICS,
    RESPIRATORY IMPAIRMENT, CORNARY INSUFFICIENCY, HYPERSENSITIVITY TO
    BUTORPHENOL OR BUTORPHENOL SALTS.

=======================  First Aid Measures  =======================

First Aid:EYES-FLUSH WITH LOTS OF WATER FOR 15-20 MINUTES. SKIN-WASH
    WITH SOAP & WATER FOR 15-20 MINUTES. INGESTED-GET IMMEDIATE MEDICAL
    ATTENTION. CONSIDER NALOXONE AS AN ANTIDOTE. INHALED-REMOVE TO
    FRESH AIR.	GIVE ARTIFICIAL RESPIRATION IF NOT BREATHING; OXYGEN IF
    BREATHING DIFFICULT. GET IMMEDIATE MEDICAL ATTENTION.

=====================  Fire Fighting Measures  =====================

Flash Point:NOT AVAILABLE
Extinguishing Media:USE WATER.
Fire Fighting Procedures:WEAR SELF-CONTAINED BREATHING APPARATUS AND
    FULL PROTECTIVE GEAR. COOL FIRE EXPOSED CONTAINERS WITH WATER.
    DIVERT RUNOFF TO A SAFE AREA.
Unusual Fire/Explosion Hazard:NONE SPECIFIED BY MANUFACTURER.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR SUITABLE PROTECTIVE CLOTHING (LATEX
    GLOVES & EYE PROTECTION AS A MINIUMUM). ABSORB ON APPROPRIATE
    ABSORBENT MATERIAL AND PLACE IN A CONTAINER FOR DISPOSAL. SPILL
    AREA SHOULD BE VENTILATED AND DEC ONTAMINATED AFTER MATERIAL
    PICK-UP.
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN A COOL, DRY PLACE AT ROOM
    TEMPERATURE.
Other Precautions:PERSONS ALLERGIC TO BUTORPHENOL, BUTORPHENOL SALTS OR
    ANY OTHER INGREDIENTS IN THIS FORMULATION, SHOULD AVOID CONTACT
    WITH THIS SUBSTANCE. INTENDED FOR USE UNDER DIRECTION OF A
    PHYSICIAN AND/OR CONDIT IONS OF USE ON THE LABEL/INSERT.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:NONE NORMALLY REQUIRED.
Ventilation:NONE NORMALLY REQUIRED.
Protective Gloves:LATEX.
Eye Protection:GOGGLES WHEN HANDLING BULK QUANTITIES.
Other Protective Equipment:ADDITIONAL PROTECTIVE CLOTHING MAY BE NEEDED
    WHEN HANDLING LARGE QUANTITIES OF PRODUCT OR IF SPLASHING EXISTS.
Work Hygienic Practices:WASH HANDS AFTER HANDLING AND BEFORE EATING,
    DRINKING, OR SMOKING. LAUNDER CONTAMINATED CLOTHES BEFORE REUSE.
Supplemental Safety and Health
PERSONNEL WHO HANDLE THIS SOLUTION IN A MANUFACTURING FACILITY SHOULD
    WEAR PROTECTIVE CLOTHING, INCLUDING IMPERMEABLE GLOVES, EYE
    PROTECTION, AND A GOWN. PERSONNEL IN A CLINICAL FACILITY SHOULD
    WEAR I MPERMEABLE GLOVES & EYE PROTECTION.
    NDCNUMBER:NDC00087-5650-41.

==================  Physical/Chemical Properties  ==================

HCC:T6
Boiling Pt:B.P. Text:212F,100C
Melt/Freeze Pt:M.P/F.P Text:32.0F,0.0C
pH: 5
Solubility in Water:MODERATE
Appearance and Odor:COLORLESS OR NEAR COLORLESS AQUEOUS SOLUTION IN AN
    AMBER GLASS BOTTLE W/PUMP.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
NONE KNOWN.
Stability Condition to Avoid:NONE SPECIFIED BY MANUFACTURER.
Hazardous Decomposition Products:THERMAL DECOMPOSITION MAY
    PRODUCE-CARBON MONOXIDE,CARBON DIOXIDE,HYDROGEN CHLORIDE,OXIDES OF
    NITROGEN.
Conditions to Avoid Polymerization:WILL NOT OCCUR.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE WITH LOCAL, STATE,
    FEDERAL OR HOST COUNTRY ENVIRONMENTAL REGULATIONS.

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