Apo-Loperamide

UNITED STATES PHARMACOPEIAL CONVENTION INC -- 37000 LOPERAMIDE HYDROCHLORIDE 200 MG -- 6850-00F055437
=====================  Product Identification  =====================

Product ID:37000 LOPERAMIDE HYDROCHLORIDE 200 MG
MSDS Date:03/11/1997
FSC:6850
NIIN:00F055437
MSDS Number: CGJHQ
=== Responsible Party ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Info Phone Num:301-881-0666
Emergency Phone Num:301-881-0666
Preparer's Name:JEROME HALPERIN
CAGE:14128
=== Contractor Identification ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
Box:City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Phone:301-881-0666
CAGE:14128

=============  Composition/Information on Ingredients  =============

Ingred Name:LOPERAMIDE HYDROCHLORIDE   *97-4*
CAS:34552-83-5
RTECS #:TM4960000

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50(MOUSE): 105 MG/KG
Routes of Entry: Inhalation:YES  Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:INHALATION: MAY CAUSE RESPIRATORY
    TRACT IRRITATION. POSSIBLE HYPERSENSITIZATION & DEHYDRATION.
    EYES/SKIN: IRRITATION. INGESTION: GASTROINTESTINAL IRRITANT.
    POSSIBLE ALLERGIC REACTION TO MATERIAL IF IN HALED, INGESTED/IN
    CONTACT W/SKIN. CNS DEPRESSION MAY OCCUR BY OVERDOSE. USUAL ORAL
    ADULT DOSE IS 4-8 MG/PER DAY.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:BLOATING, ADDOMINAL PAIN, NAUSEA, VOMITING,
    DIZZINESS, DRY MOUTH, SKIN RASH, DROWSINESS, CONSTIPATION,
    DEHYDRATION, IRRITATION
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY TO THE MATERIAL,
    DEHYDRATION, SEVERE COLITIS, ANTIBIOTIC ASSOCIATED DIARRHEA/ACUTE
    DYSENTERY.

=======================  First Aid Measures  =======================

First Aid:INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE
    CPR/OXYGEN IF NECESSARY. SKIN/EYES: FLUSH W/COPIOUS QUANTITIES OF
    WATER. INGESTION: FLUSH OUT MOUTH W/WATER. OBTAIN MEDICAL ATTENTION
    IN ALL CAS ES. OVERDOSE TREATMENT: 1) PROLONGED/CAREFUL MONITORING.
    2)PROMPT ADMINISTRATION OF ACTIVATED CHARCOAL FOLLOWING INGESTION.
    3) GASTRIC LAVAGE IF VOMITING. 4)SUPPORT RESPIRATION. 5) USE
    NALOXONE.

=====================  Fire Fighting Measures  =====================

Lower Limits:<15 G/CUM
Extinguishing Media:WATER SPRAY, DRY CHEMICAL, CO2/FOAM AS APPROPRIATE
    FOR SURROUNDING FIRE & MATERIALS
Fire Fighting Procedures:EVACUATE PERSONNEL TO A SAFE AREA. USE SELF
    CONTAINED BREATHING EQUIPMENT & PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:AS W/ALL DRY POWDERS IT IS ADVISABLE TO
    GROUND MECHANICAL EQUIPMENT IN CONTACT W/DRY MATERIAL TO DISSIPATE
    THE POTENTIAL BUILDUP OF STATIC ELECTRICITY. (SUPP)

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR APPROVED RESPIRATORY PROTECTION,
    CHEMICALLY COMPATIBLE GLOVES & PROTECTIVE CLOTHING. WIPE UP/COLLECT
    LEAK USING A HIGH EFFICIENCY VACUUM CLEANER. AVOID BREATHING DUST.
    PLACE RELEASE IN APPROPRIAT ELY LABELLED CONTAINER FOR DISPOSAL.
    WASH SITE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN TIGHT CONTAINER. THIS
    MATERIAL SHOULD BE HANDLED & STORED PER LABEL INSTRUCTIONS TO
    ENSURE PRODUCT INTEGRITY.
Other Precautions:WHEN HANDLING, AVOID ALL CONTACT & INHALATION OF
    DUST, MISTS & VAPORS ASSOCIATED W/THE MATERIAL.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:USE A NIOSH APPROVED RESPIRATOR IF NECESSARY. IF
    RESPIRATOR IS UNAVAILABLE, AN APPROVED DUST MASK SHOULD BE USED.
Ventilation:RECOMMENDED
Protective Gloves:RUBBER
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:PROTECTIVE CLOTHING
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
AUTOIGNITION TEMP: 734F.

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:M.P/F.P Text:431.6-442F
Solubility in Water:SLIGHT
Appearance and Odor:WHITE TO SLIGHTLY YELLOW POWDER

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
ACIDS, BASES, OXIDIZING AGENTS
Stability Condition to Avoid:STATIC ELECTRICITY
Hazardous Decomposition Products:CHLORINE, NITROGEN OXIDIES, HYDROGEN
    CHLORIDE
Conditions to Avoid Polymerization:WHEN HEATED TO DECOMPOSITION,
    MATERIAL EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE W/LOCAL, STATE &
    FEDERAL REGULATIONS.

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 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
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 particular situation.