Alfenta

JANSSEN PHARMACEUTICA INC -- ALFENTANIL HYDROCHLORIDE -- 6505-01-265-0009
=====================  Product Identification  =====================

Product ID:ALFENTANIL HYDROCHLORIDE
MSDS Date:07/01/1992
FSC:6505
NIIN:01-265-0009
MSDS Number: BXPCK
=== Responsible Party ===
Company Name:JANSSEN PHARMACEUTICA INC
Address:1125 TRENTON-HARBOURTON RD
City:TITUSVILLE
State:NJ
ZIP:08560-0200
Country:US
Info Phone Num:609-730-2142
Emergency Phone Num:609-730-2142
CAGE:GO500
=== Contractor Identification ===
Company Name:JANSSEN PHARMACEUTICA INC
Box:UNKNOW
CAGE:59484
Company Name:JANSSEN PHARMACEUTICAIAAN 3
Address:2440
City:GEAL
Country:US
Phone:800-227-6701
CAGE:GO500

=============  Composition/Information on Ingredients  =============

Ingred Name:ALFENTANIL HYDROCHLORIDE		  *95-1*
CAS:69049-06-5
RTECS #:TX1452500

=====================  Hazards Identification  =====================

Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:CHARACTERISTIC RIGIDITY OF THE
    SKELETAL MUSCLES, CARDIAC & RESPIRATORY DEPRESSION, NARROWING OF
    THE PUPILS, CONSEQUENCES: LOWING OF BODY TEMP, COMA & DEATH. THIS
    SUBSTANCE IS A POTENT, VERY RAPIDLY &  SHORT ACTING ANALGESIC. VERY
    SHORT-ACTING & POTENT MORPHINE-LIKE ANALGESIC (PAINKILLER).
Explanation of Carcinogenicity:NONE
Effects of Overexposure:CHARACTERISTIC RIGIDITY OF THE SKELETAL
    MUSCLES, CARDIAC & RESPIRATORY DEPRESSION, NARROWING OF THE PUPILS,
    CONSEQUENCES: LOWING OF BODY TEMP, COMA & DEATH. NOTE TO PHYSICIAN:
    SPECIFIC ANTIDOTE-NALORP HINE HYDROBROMIDE: 5-10 MG I.V.,I.M/S.C.
    IF NEEDED REPEAT 10-15 MIN LATER UP TO 40 MG. (SEE SUPP)

=======================  First Aid Measures  =======================

First Aid:INGESTION: RINSE MOUTH W/WATER. EYES: RINSE THOROUGHLY
    W/RUNNING WATER FOR 10-15 MINS. SKIN: WASH W/WATER & SOAP.
    INHALATION: IMMEDIATELY REMOVE TO FRESH AIR. GIVE CPR IF NEEDED.
    KEEP WARM & QUIET. OB TAIN MEDICAL ATTENTION IN ALL CASES.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER, POWDER, HALONES, CO2, SAND, FOAM
Fire Fighting Procedures:WEAR GLOVES, PROTECTIVE CLOTHING & RESPIRATORY
    PROTECTION. COOL CONTAINERS W/ATOMIZED WATER.
Unusual Fire/Explosion Hazard:AVOID DISPERSION OF THE PRODUCT.

==================  Accidental Release Measures  ==================

Spill Release Procedures:UPON RUPTURE, CAREFULLY COLLECT & SCOOP UP
    PRODUCT & STORE IN A CLOSED CONTAINER FOR DESTRUCTION AS CHEMICAL
    WASTE. WHEN CLEANING UP, ALWAYS WEAR SUITABLE GLOVES/DISPOSABLE
    CLOTHES W/HOOD & COMPRESSED  AIR MASK /HOOD, BREATHE EASY
    5/EQUIVALENTS.(SUPP)

======================	Handling and Storage  ======================

Handling and Storage Precautions:IMMEDIATELY TAKE OFF CONTAMINATED
    CLOTHING. WEAR SUITABLE RESPIRATORY EQUIPMENT.
Other Precautions:AVOID CONTACT W/SKIN. WEAR SUITABLE PROTECTIVE
    CLOTHING & GLOVES & RESPIRATORY EQUIPMENT. AVOID DISPERSION OF THE
    PRODUCT.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:SMALL: USE GAS MASK W/P3 DUST FILTER. OTHER:
    COMPRESSED-AIR MASK/HOOD/BREATHE-EASY 5 NO DISPOSABLE MASK.
Protective Gloves:DISPOSABLE
Eye Protection:NO DISPOSABLE MASK
Other Protective Equipment:CLOSED WORKING/DISPOSABLE CLOTHES W/HOOD
    OVER ENTIRE WORKING CLOTHES.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
    REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
SPILL CONT'D: UPON DISPERSION OF THE PRODUCT, FIRST DEMARCATE THE
    ENVIRONMENT BEFORE STARTING TO CLEAN UP. COLLECT THE DISPOSABLE
    CLOTHES IN A PLASTIC BAG FOR DESTRUCTION. IMMEDIATELY NOTIFY THE
    SUPER VISOR. HEALTH HAZARDS CONT'D: NALOXONE HYDROCHLORIDE-400 UG
    S.C., I.V./I.M., IF NEEDED REPEAT AFTER 2-3 MINS.

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:M.P/F.P Text:275-284F
pH:3.6
Solubility in Water:130 G/L
Appearance and Odor:WHITE POWDER

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
OXIDANTS, REDUCING AGENTS, ALKALINES
Hazardous Decomposition Products:NITROUS OXIDES, CHLORINE, HYDROGEN
    CHLORIDE, CO
Conditions to Avoid Polymerization:GROUND

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
    REGULATIONS. UN: 2811.

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