m-Aminosalicylic acid
m-Aminosalicylic acid Brand names, m-Aminosalicylic acid Analogs
m-Aminosalicylic acid Brand Names Mixture
- No information avaliable
m-Aminosalicylic acid Chemical_Formula
C6H11NO3
m-Aminosalicylic acid RX_link
No information avaliable
m-Aminosalicylic acid fda sheet
m-Aminosalicylic acid msds (material safety sheet)
m-Aminosalicylic acid Synthesis Reference
No information avaliable
m-Aminosalicylic acid Molecular Weight
145.156 g/mol
m-Aminosalicylic acid Melting Point
No information avaliable
m-Aminosalicylic acid H2O Solubility
Freely soluble
m-Aminosalicylic acid State
Solid
m-Aminosalicylic acid LogP
-1.026
m-Aminosalicylic acid Dosage Forms
Cream for topical administration (160 mg/g of methyl aminolevulinate equivalent to 16.0% of methyl aminolevulinate)
m-Aminosalicylic acid Indication
For topical use, in combination with 570 to 670 nm wavelength red light illumination, in the treatment of non-hyperkeratotic actinic keratoses of the face and scalp in immunocompetent patients when used in conjunction with lesion preparation (debridement using a sharp dermal curette).
m-Aminosalicylic acid Pharmacology
After topical application of methyl aminolevulinate, porphyrins will accumulate intracellularly in the treated skin lesions. The intracellular porphyrins (including PpIX) are photoactive, fluorescing compounds and, upon light activation in the presence of oxygen, singlet oxygen is formed which causes damage to cellular compartments, in particular the mitochondria. Light activation of accumulated porphyrins leads to a photochemical reaction and thereby phototoxicity to the light-exposed target cells.
m-Aminosalicylic acid Absorption
In vitro, after 24 hours the mean cumulative absorption through human skin was 0.26% of the administered dose.
m-Aminosalicylic acid side effects and Toxicity
The severity of local phototoxic reactions such as erythema, pain and burning sensation may increase in case of prolonged application time or very high light intensity.
m-Aminosalicylic acid Patient Information
m-Aminosalicylic acid Organisms Affected
Humans and other mammals
