l-Prostaglandin E1 en es it fr

l-Prostaglandin E1 Brand names, l-Prostaglandin E1 Analogs

l-Prostaglandin E1 Brand Names Mixture

  • No information avaliable

l-Prostaglandin E1 Chemical_Formula


l-Prostaglandin E1 RX_link


l-Prostaglandin E1 fda sheet

l-Prostaglandin_E1 FDA

l-Prostaglandin E1 msds (material safety sheet)

l-Prostaglandin_E1 MSDS

l-Prostaglandin E1 Synthesis Reference

No information avaliable

l-Prostaglandin E1 Molecular Weight

354.481 g/mol

l-Prostaglandin E1 Melting Point

115 - 116 oC

l-Prostaglandin E1 H2O Solubility

26.7 mg/L

l-Prostaglandin E1 State


l-Prostaglandin E1 LogP


l-Prostaglandin E1 Dosage Forms

Liquid; Powder for solution; Solution; Suppository

l-Prostaglandin E1 Indication

For palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.

l-Prostaglandin E1 Pharmacology

Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora. As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through the subtunical vessels is impeded and penile rigidity develops. This is referred to as the corporal veno-occlusive mechanism. In infants, the vasodilatory effects of alprostadil increase pulmonary or systemic blood flow.

l-Prostaglandin E1 Absorption

The absolute bioavailability of alprostadil has not been determined.

l-Prostaglandin E1 side effects and Toxicity

Oral, mouse: LD50 = 186 mg/kg; Oral, rat: LD50 = 228 mg/kg. Apnea, bradycardia, pyrexia, hypotension, and flushing may be signs of drug overdosage.

l-Prostaglandin E1 Patient Information

l-Prostaglandin E1 Organisms Affected

Humans and other mammals