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  • Novasmasol Formula chimica

    C11H17NO3

    Novasmasol RX link

    http://www.rxlist.com/cgi/generic2/metaproterenol.htm

    Novasmasol FDA foglio

    Novasmasol DMS (foglio di materiale di sicurezza)

    Novasmasol MSDS

    Novasmasol Sintesi di riferimento

    O. Thoma, K. Zeile, US Pat. 3,341,594 (1967)

    Novasmasol Peso molecolare

    211.258 g/mol

    Novasmasol Temperatura di fusione

    100oC

    Novasmasol H2O Solubilita

    9.7mg / L

    Novasmasol Stato

    Solid

    Novasmasol LogP

    1.172

    Novasmasol Forme di dosaggio

    Inalazione

    Novasmasol Indicazione

    Per il trattamento di broncospasmo, bronchite cronica, asma e l'enfisema.

    Novasmasol Farmacologia

    Metaproterenolo, un'ammina sintetico, è strutturalmente e farmacologicamente simile a isoproterenolo. Metaproterenolo è utilizzato esclusivamente come un broncodilatatore. Gli effetti farmacologici di beta agonisti adrenergici farmaci, come metaproterenolo, sono almeno in parte attribuibile alla stimolazione attraverso i recettori beta adrenergici di ciclasi intracellulare, l'enzima che catalizza la conversione di adenosina trifosfato (ATP) a ciclico-3 ', 5'-adenosina monofosfato (c-AMP). Aumentato i livelli di AMP-c sono associati con il rilassamento della muscolatura liscia bronchiale e inibizione del rilascio di mediatori di immediata ipersensibilità dalle cellule, in particolare dai mastociti.

    Novasmasol Assorbimento

    3% (biodisponibilità orale del 40%)

    Novasmasol Tossicita

    Sintomi di sovradosaggio includono angina, ipertensione o ipotensione, aritmie, nervosismo, mal di testa, tremore, bocca secca, palpitazioni, nausea, vertigini, stanchezza, malessere e insonnia. LD50 = 42 mg / kg (per via orale nel ratto).

    Novasmasol Informazioni paziente

    Patient�s Instructions for Use Alupent�

    (metaproterenol sulfate USP) Inhalation Aerosol

    1. Insert metal canister into clear end of mouthpiece.

    2. Remove protective cap, invert canister and shake well before each use.

    3. Avoid spraying in eyes.

    4. Enclose mouthpiece with the lips. The base of the canister should be held vertically. The Alupent� canister is to be used only with the white Alupent� Inhalation Aerosol mouthpiece. This mouthpiece should not be used with other aerosol medications.

    5. Exhale deeply, then inhale slowly through the mouth and at the same time firmly press once on the upended canister base; continue to inhale deeply. Hold your breath for a few seconds and then remove the mouthpiece from the mouth and exhale slowly.

    One inhalation is often enough to obtain relief. The inhalation can be repeated once or twice, if necessary, or as your physician directs. Wait at least two minutes before repeating the inhalation. In most cases, the dose should not be repeated more often than every 3 to 4 hours. No more than 12 inhalations should be taken in one day.

    6. Replace protective cap after use.

    WARNING
    Do not exceed the dose prescribed by your physician. If difficulty in breathing persists, contact your physician immediately.

    Note: When full, the container holds enough medication for at least 200 inhalations: at least 100 inhalations are in the sample unit. Check regularly, by shaking the cylinder or container, to determine whether it contains any medication. When it first seems empty, there are still about ten doses left. Refill containers for the plastic mouthpiece are available when prescribed by your physician.

    Keep the mouthpiece clean. Wash with hot water. If soap is used, rinse thoroughly with plain water.

    Never open the container holding the medication. Opening it is dangerous and renders the contents useless.

    Caution: Contents Under Pressure. Do not puncture or incinerate container. Do not expose to heat or store at temperatures above 120�F. Keep out of reach of small children

    Note: The indented statement below is required by the Federal government�s Clean Air Act for all products containing or manufactured with chlorofluorocarbons (CFCs): This product contains trichloromonofluoromethane (CFC-11), dichlorodifluoromethane (CFC-12) and dichlorotetrafluoroethane (CFC-114), substances which harm the environment by destroying ozone in the upper atmosphere.

    Your physician has determined that this product is likely to help your personal health. USE THIS PRODUCT AS DIRECTED, UNLESS INSTRUCTED TO DO OTHERWISE BY YOUR PHYSICIAN. If you have any questions about alternatives, consult with your physician

    Novasmasol Atto interessato organismi

    Gli esseri umani e altri mammiferi