Flindix
Categorie
Flindix Les marques, Flindix Analogs
- Cardio 10
- Cardis
- Carvanil
- Carvasin
- Cedocard
- Claodical
- Cornilat
- Coronex
- Corosorbide
- Dianhydrosorbitol 2,5-dinitrate
- Difutrat
- Dilatrate
- Dilatrate-SR
- Dinitrosorbide
- Emoper
- Flindix
- Harrical
- IBD 20
- ISD
- ISDN
- Ismotic
- Iso-Bid
- Isochron
- Isoket
- Isorbid;
- Isordil
- Isordil Tembids
- Isosorbide dinitrate(USAN)
- Isostat
- Isotrate
- Korodil
- Lomilan
- Maycor
- Myorexon
- Nitrosorbid
- Nitrosorbide
- Nitrosorbon
- Nosim
- Resoidan
- Rifloc Retard
- Rigedal
- Sorbangil
- Sorbide T.D.
- Sorbide nitrate
- Sorbide, dinitrate
- Sorbidilat
- Sorbidnitrate
- Sorbislo
- Sorbitrate
- Sorbonit
- Sorquad
- Tinidil
- Titradose
- Vascardin
- Vasodilat
- Vasorbate
- Xanyl
Flindix Les marques melange
Flindix Formule chimique
C6H8N2O8
Flindix RX lien
http://www.rxlist.com/cgi/generic2/isodinit.htm
Flindix FDA fiche
Flindix msds (fiche de securite des materiaux)
Flindix Synthese de reference
Goldberg, Acta Physiol. Scand.15, 173 (1948)
Flindix Poids moleculaire
236.136 g/mol
Flindix Point de fusion
70 oC
Flindix H2O Solubilite
1,089 mg / mL
Flindix Etat
Solid
Flindix LogP
-0.53
Flindix Formes pharmaceutiques
Comprimé oral
Flindix Indication
Pour la prévention de l'angine de poitrine due à une maladie coronarienne.
Flindix Pharmacologie
Dinitrate d'isosorbide est modéré à longue durée d'action nitrates organiques utilisés par voie orale pour le soulagement et le traitement prophylactique de l'angine de poitrine. Il détend le muscle lisse vasculaire et la dilatation consécutive des artères et des veines périphériques, surtout la dernière. Dilatation des veines périphériques favorise l'accumulation de sang et diminue le retour veineux vers le cœur, réduisant ainsi ventriculaire gauche diastolique pression et la pression capillaire pulmonaire (précharge). Relâchement des artérioles réduit la résistance vasculaire systémique, la pression artérielle systolique et la pression artérielle moyenne.
Flindix Absorption
L'absorption de dinitrate d'isosorbide après administration orale est presque complète, mais sa biodisponibilité est très variable (10% à 90%), avec un effet de premier passage hépatique dans le foie. La biodisponibilité moyenne de dinitrate d'isosorbide est d'environ 25%.
Flindix Toxicite
Les symptômes de surdose comprennent la réduction du débit cardiaque et une hypotension.
Flindix Information pour les patients
PATIENT INFORMATION
Patients should be told that the anti-anginal efficacy of isosorbide dinitrate is strongly related
to its dosing regimen, so the prescribed schedule of dosing should be followed carefully. In
particular, daily headaches sometimes accompany treatment with isosorbide dinitrate. In patients
who get these headaches, the headaches are a marker of the activity of the drug. Patients should
resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide
dinitrate, since loss of headache may be associated with simultaneous loss of anti-anginal efficacy.
Aspirin and/or acetaminophen, on the other hand, often successfully relieve isosorbide dinitrate-
induced headaches with no deleterious effect an isosorbide dinitrate's anti-anginal efficacy.
Treatment with isosorbide dinitrate may be associated with lightheadedness on standing, especially
just after rising from a recumbent or seated position. This effect may be more frequent in patients
who have also consumed alcohol
Patients should be told that the anti-anginal efficacy of isosorbide dinitrate is strongly related
to its dosing regimen, so the prescribed schedule of dosing should be followed carefully. In
particular, daily headaches sometimes accompany treatment with isosorbide dinitrate. In patients
who get these headaches, the headaches are a marker of the activity of the drug. Patients should
resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide
dinitrate, since loss of headache may be associated with simultaneous loss of anti-anginal efficacy.
Aspirin and/or acetaminophen, on the other hand, often successfully relieve isosorbide dinitrate-
induced headaches with no deleterious effect an isosorbide dinitrate's anti-anginal efficacy.
Treatment with isosorbide dinitrate may be associated with lightheadedness on standing, especially
just after rising from a recumbent or seated position. This effect may be more frequent in patients
who have also consumed alcohol
Flindix Organismes affectes
Les humains et autres mammifères
