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Diladel Les marques, Diladel Analogs

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  • Diladel Formule chimique

    C22H26N2O4S

    Diladel RX lien

    http://www.rxlist.com/cgi/generic/diltiaz.htm

    Diladel FDA fiche

    Diladel FDA

    Diladel msds (fiche de securite des materiaux)

    Diladel MSDS

    Diladel Synthese de reference

    H. Kugita et al., US. 3,562,257 (1971)

    Diladel Poids moleculaire

    414.519 g/mol

    Diladel Point de fusion

    231oC

    Diladel H2O Solubilite

    465 mg / L

    Diladel Etat

    Solid

    Diladel LogP

    3.141

    Diladel Formes pharmaceutiques

    Solution

    Diladel Indication

    Pour le traitement de l'hypertension

    Diladel Pharmacologie

    Diltiazem, un benzothiazépine inhibiteur calcique, est utilisé seul ou avec une conversion de l'angiotensine inhibiteur de l'enzyme, pour traiter l'hypertension, angine de poitrine chronique stable, et l'angine de Prinzmetal variante. Diltiazem est similaire à d'autres vasodilatateurs périphériques. Diltiazem inhibe l'influx de calcium extracellulaire à travers le myocarde et lisse vasculaire membranes des cellules musculaires éventuellement par déformation de la canal, l'inhibition des mécanismes de déclenchement d'ions de contrôle, et / ou interférer avec la libération de calcium par le réticulum sarcoplasmique. La diminution du calcium intracellulaire inhibe les processus contractiles des cellules du muscle lisse du myocarde, la dilatation provoque des artères coronaires et systémiques, l'augmentation de l'apport d'oxygène vers les tissus du myocarde, une diminution de la résistance périphérique totale, une diminution systémique la pression artérielle, et une diminution de la postcharge.

    Diladel Absorption

    Diltiazem est bien absorbé par le tractus gastro-intestinal, mais subit substantielle de premier passage hépatique effet.

    Diladel Toxicite

    DL50 = 740mg/kg (par voie orale chez la souris)

    Diladel Information pour les patients

    PATIENT INFORMATION

    Take this medicine exactly as directed even if you feel well and do not notice any signs of chest pain.

    Do not take more of this medicine and do not take it more often than your doctor ordered.

    Do not miss any doses.

    Diltiazem is a calcium channel blocking agents. For the calcium channel blocking agents, the following should be considered:

    -Tell your doctor if you have ever had any unusual or allergic reaction to amlodipine, bepridil, diltiazem, felodipine, flunarizine, isradipine, nicardipine, nifedipine, nimodipine, or verapamil. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

    -Calcium channel blocking agents have not been studied in pregnant women. However, studies in animals have shown that large doses of calcium channel blocking agents cause birth defects, prolonged pregnancy, poor bone development in the offspring, and stillbirth.

    -Although bepridil, diltiazem, nifedipine, verapamil, and possibly other calcium channel blocking agents, pass into breast milk, they have not been reported to cause problems in nursing babies.

    -Although there is no specific information comparing use of this medicine in children with use in other age groups, it is not expected to cause different side effects or problems in children than it does in adults.

    -Elderly people may be especially sensitive to the effects of calcium channel blocking agents. This may increase the chance of side effects during treatment. A lower starting dose may be required.

    -The presence of other medical problems may affect the use of the calcium channel blocking agents. Make sure you tell your doctor if you have any other medical problems, especially

    Follow Rxlist link and drugs.com link and other links for detailed information.

    Diladel Organismes affectes

    Les humains et autres mammifères