DUP 89
Categorie
DUP 89 Les marques, DUP 89 Analogs
DUP 89 Les marques melange
DUP 89 Formule chimique
C22H23ClN6O
DUP 89 RX lien
http://www.rxlist.com/cgi/generic/losar.htm
DUP 89 FDA fiche
DUP 89 msds (fiche de securite des materiaux)
DUP 89 Synthese de reference
DJ Carini et al., US. 5,138,69 (1992)
DUP 89 Poids moleculaire
422.911 g/mol
DUP 89 Point de fusion
183.5-184.5 oC
DUP 89 H2O Solubilite
DUP 89 Etat
Solid
DUP 89 LogP
5.438
DUP 89 Formes pharmaceutiques
Tablet
DUP 89 Indication
Pour le traitement de l'hypertension.
DUP 89 Pharmacologie
Le losartan est le premier d'une classe d'agents antihypertenseurs, l'angiotensine II (AG II) des antagonistes du récepteur. Il est, avec ses plus agissant métabolite actif (E-3174), une sélection spécifique et Antagoniste des récepteurs AT1. Le losartan bloque l'effet vasoconstricteur et de sécrétion d'aldostérone effets de l'angiotensine II en bloquant sélectivement la liaison de l'angiotensine II au récepteur AT1 trouve dans de nombreux tissus (par exemple, le muscle lisse vasculaire, glande surrénale).
DUP 89 Absorption
Eh bien absorbée, la biodisponibilité systémique du losartan est d'environ 33%
DUP 89 Toxicite
Hypotension et une tachycardie bradycardie peut survenir à partir parasympathique (vagal), DL50 = 1000 mg / kg (par voie orale chez le rat)
DUP 89 Information pour les patients
PATIENT INFORMATION
Losartan potassium is used to treat high blood pressure. It may be used alone
or with other medications for high blood pressure. This medication should,
generally, not be used during pregnancy. If you are pregnant or considering
becoming pregnant, inform your physician immediately to discuss the risks
versus benefits. There are few side effects associated with losartan potassium.
Those most frequently reported, cough, upper respiratory infection and
dizziness, occurred no more frequently than in patients who did not take this
medication. You may take this medication with or without food. You should have
your blood pressure checked regularly
Losartan potassium is used to treat high blood pressure. It may be used alone
or with other medications for high blood pressure. This medication should,
generally, not be used during pregnancy. If you are pregnant or considering
becoming pregnant, inform your physician immediately to discuss the risks
versus benefits. There are few side effects associated with losartan potassium.
Those most frequently reported, cough, upper respiratory infection and
dizziness, occurred no more frequently than in patients who did not take this
medication. You may take this medication with or without food. You should have
your blood pressure checked regularly
DUP 89 Organismes affectes
Les humains et autres mammifères
