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Crixivan Les marques, Crixivan Analogs

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  • Crixivan Formule chimique

    C36H47N5O4

    Crixivan RX lien

    http://www.rxlist.com/cgi/generic2/indinav.htm

    Crixivan FDA fiche

    Crixivan FDA

    Crixivan msds (fiche de securite des materiaux)

    Crixivan MSDS

    Crixivan Synthese de reference

    JP Vacca et al USPat. 5,413,999 (1995)

    Crixivan Poids moleculaire

    613.79 g/mol

    Crixivan Point de fusion

    167.5-168 oC

    Crixivan H2O Solubilite

    0,015 mg / ml

    Crixivan Etat

    Solid

    Crixivan LogP

    2.569

    Crixivan Formes pharmaceutiques

    Capsules orales

    Crixivan Indication

    Pour le traitement de l'infection à VIH.

    Crixivan Pharmacologie

    L'indinavir est un inhibiteur de protéase ayant une activité contre virus d'immunodéficience humaine de type 1 (VIH-1). Les inhibiteurs de protéase bloquent la partie appelée protéase du VIH. VIH-1 de la protéase est une enzyme requise pour la le clivage protéolytique des précurseurs dans la polyprotéine virale fonctionnelle des protéines individuelles dans infectieuses VIH-1. L'indinavir se lie au site de la protéase active et inhibe l'activité de l'enzyme. Cette inhibition empêche le clivage des polyprotéines viraux résultant en la formation d'immatures non-particules virales infectieuses. Les inhibiteurs de protéase sont presque toujours utilisés en combinaison avec au moins deux autres médicaments anti-VIH.

    Crixivan Absorption

    Rapidement absorbé

    Crixivan Toxicite

    Les symptômes de surdose comprennent l'infarctus du myocarde et angine de poitrine.

    Crixivan Information pour les patients

    A statement to patients and health care providers is included on the product’s bottle label. ALERT: Find out about medicines that should NOT be taken with CRIXIVAN. A Patient Package Insert (PPI) for CRIXIVAN is available for patient information.

    CRIXIVAN is not a cure for HIV infection and patients may continue to develop opportunistic infections and other complications associated with HIV disease. The long-term effects of CRIXIVAN are unknown at this time. CRIXIVAN has not been shown to reduce the risk of transmission of HIV to others through sexual contact or blood contamination.

    Patients should be advised to remain under the care of a physician when using CRIXIVAN and should not modify or discontinue treatment without first consulting the physician. Therefore, if a dose is missed, patients should take the next dose at the regularly scheduled time and should not double this dose. Therapy with CRIXIVAN should be initiated and maintained at the recommended dosage.

    CRIXIVAN may interact with some drugs; therefore, patients should be advised to report to their doctor the use of any other prescription, non-prescription medication or herbal products, particularly St. John’s wort.

    For optimal absorption, CRIXIVAN should be administered without food but with water 1 hour before or 2 hours after a meal. Alternatively, CRIXIVAN may be administered with other liquids such as skim milk, juice, coffee, or tea, or with a light meal, e.g., dry toast with jelly, juice, and coffee with skim milk and sugar; or corn flakes, skim milk and sugar. Ingestion of CRIXIVAN with a meal high in calories, fat, and protein reduces the absorption of indinavir.

    Patients receiving a phosphodiesterase type 5 (PDE5) inhibitor (sildenafil, tadalafil, or vardenafil) should be advised that they may be at an increased risk of PDE5 inhibitor-associated adverse events including hypotension, visual changes, and priapism, and should promptly report any symptoms to their doctors.

    Patients should be informed that redistribution or accumulation of body fat may occur in patients receiving antiretroviral therapy and that the cause and long-term health effects of these conditions are not known at this time.

    CRIXIVAN Capsules are sensitive to moisture. Patients should be informed that CRIXIVAN should be stored and used in the original container and the desiccant should remain in the bottle.

    Crixivan Organismes affectes

    Virus d'immunodéficience humaine