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Indinavir Nombres de marca, Indinavir Analogos

Indinavir Marca los nombres de mezcla

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  • Indinavir Formula quimica

    C36H47N5O4

    Indinavir RX enlace

    http://www.rxlist.com/cgi/generic2/indinav.htm

    Indinavir FDA hoja

    Indinavir FDA

    Indinavir MSDS (hoja de seguridad de materiales)

    Indinavir MSDS

    Indinavir Sintesis de referencia

    JP Vacca et al USpat. 5,413,999 (1995)

    Indinavir Peso molecular

    613.79 g/mol

    Indinavir Punto de fusion

    167.5-168 oC

    Indinavir H2O Solubilidad

    0,015 mg / ml

    Indinavir Estado

    Solid

    Indinavir LogP

    2.569

    Indinavir Formas de dosificacion

    Cápsulas orales

    Indinavir Indicacion

    Para el tratamiento de la infección por VIH.

    Indinavir Farmacologia

    Indinavir es un inhibidor de la proteasa con actividad contra el virus de inmunodeficiencia humana tipo 1 (VIH-1). Inhibidores de la proteasa bloquean la parte del VIH llamada proteasa. VIH-1 proteasa es una enzima necesaria para la escisión proteolítica de los precursores de poliproteína viral en las proteínas funcionales individuales se encuentran en infecciosa del VIH-1. Se une al sitio activo de la proteasa e inhibe la actividad de la enzima. Esta inhibición impide la división de las poliproteínas viral que resulta en la formación de inmaduros no partículas virales infecciosas. Inhibidores de la proteasa se utilizan casi siempre en combinación con al menos dos otros medicamentos anti-VIH.

    Indinavir Absorcion

    Absorbe rápidamente

    Indinavir Toxicidad

    Los síntomas de sobredosis incluyen infarto de miocardio y la angina de pecho.

    Indinavir Informacion de Pacientes

    A statement to patients and health care providers is included on the product’s bottle label. ALERT: Find out about medicines that should NOT be taken with CRIXIVAN. A Patient Package Insert (PPI) for CRIXIVAN is available for patient information.

    CRIXIVAN is not a cure for HIV infection and patients may continue to develop opportunistic infections and other complications associated with HIV disease. The long-term effects of CRIXIVAN are unknown at this time. CRIXIVAN has not been shown to reduce the risk of transmission of HIV to others through sexual contact or blood contamination.

    Patients should be advised to remain under the care of a physician when using CRIXIVAN and should not modify or discontinue treatment without first consulting the physician. Therefore, if a dose is missed, patients should take the next dose at the regularly scheduled time and should not double this dose. Therapy with CRIXIVAN should be initiated and maintained at the recommended dosage.

    CRIXIVAN may interact with some drugs; therefore, patients should be advised to report to their doctor the use of any other prescription, non-prescription medication or herbal products, particularly St. John’s wort.

    For optimal absorption, CRIXIVAN should be administered without food but with water 1 hour before or 2 hours after a meal. Alternatively, CRIXIVAN may be administered with other liquids such as skim milk, juice, coffee, or tea, or with a light meal, e.g., dry toast with jelly, juice, and coffee with skim milk and sugar; or corn flakes, skim milk and sugar. Ingestion of CRIXIVAN with a meal high in calories, fat, and protein reduces the absorption of indinavir.

    Patients receiving a phosphodiesterase type 5 (PDE5) inhibitor (sildenafil, tadalafil, or vardenafil) should be advised that they may be at an increased risk of PDE5 inhibitor-associated adverse events including hypotension, visual changes, and priapism, and should promptly report any symptoms to their doctors.

    Patients should be informed that redistribution or accumulation of body fat may occur in patients receiving antiretroviral therapy and that the cause and long-term health effects of these conditions are not known at this time.

    CRIXIVAN Capsules are sensitive to moisture. Patients should be informed that CRIXIVAN should be stored and used in the original container and the desiccant should remain in the bottle.

    Indinavir Organismos afectados

    Virus de inmunodeficiencia humana