DUP 89
Categoria
DUP 89 Nombres de marca, DUP 89 Analogos
DUP 89 Marca los nombres de mezcla
DUP 89 Formula quimica
C22H23ClN6O
DUP 89 RX enlace
http://www.rxlist.com/cgi/generic/losar.htm
DUP 89 FDA hoja
DUP 89 MSDS (hoja de seguridad de materiales)
DUP 89 Sintesis de referencia
DJ Carini et al., Patente de EE.UU.. 5,138,69 (1992)
DUP 89 Peso molecular
422.911 g/mol
DUP 89 Punto de fusion
183.5-184.5 oC
DUP 89 H2O Solubilidad
0,82 mg / L
DUP 89 Estado
Solid
DUP 89 LogP
5.438
DUP 89 Formas de dosificacion
Tableta
DUP 89 Indicacion
Para el tratamiento de la hipertensión.
DUP 89 Farmacologia
Losartán es el primero de una clase de fármacos antihipertensivos llamada angiotensina II (AG II) antagonistas de los receptores. Es, junto con su acción más prolongada del metabolito activo (E-3174), un selectivo y específico Antagonista de los receptores AT1. Losartán bloquea la secreción de aldosterona vasoconstrictor y efectos de la angiotensina II bloqueando selectivamente la unión de la angiotensina II al receptor AT1 encontrado en muchos tejidos (por ejemplo, el músculo liso vascular, glándula suprarrenal).
DUP 89 Absorcion
Se absorbe bien, la biodisponibilidad sistémica del losartán es de aproximadamente un 33%
DUP 89 Toxicidad
Hipotensión y taquicardia; podría ocurrir bradicardia por estimulación parasimpática (vagal), DL50 = 1000 mg / kg (por vía oral en ratas)
DUP 89 Informacion de Pacientes
PATIENT INFORMATION
Losartan potassium is used to treat high blood pressure. It may be used alone
or with other medications for high blood pressure. This medication should,
generally, not be used during pregnancy. If you are pregnant or considering
becoming pregnant, inform your physician immediately to discuss the risks
versus benefits. There are few side effects associated with losartan potassium.
Those most frequently reported, cough, upper respiratory infection and
dizziness, occurred no more frequently than in patients who did not take this
medication. You may take this medication with or without food. You should have
your blood pressure checked regularly
Losartan potassium is used to treat high blood pressure. It may be used alone
or with other medications for high blood pressure. This medication should,
generally, not be used during pregnancy. If you are pregnant or considering
becoming pregnant, inform your physician immediately to discuss the risks
versus benefits. There are few side effects associated with losartan potassium.
Those most frequently reported, cough, upper respiratory infection and
dizziness, occurred no more frequently than in patients who did not take this
medication. You may take this medication with or without food. You should have
your blood pressure checked regularly
DUP 89 Organismos afectados
Humanos y otros mamíferos
