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Alprazolam
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Alprazolam Nombres de marca, Alprazolam Analogos

Alprazolam Marca los nombres de mezcla

  • No information avaliable
  • Alprazolam Formula quimica

    C17H13ClN4

    Alprazolam RX enlace

    http://www.rxlist.com/cgi/generic/alpraz.htm

    Alprazolam FDA hoja

    Alprazolam FDA

    Alprazolam MSDS (hoja de seguridad de materiales)

    Alprazolam MSDS

    Alprazolam Sintesis de referencia

    JB Hester, EE.UU. Pat. 3.987.052 (1976).

    Alprazolam Peso molecular

    308.765 g/mol

    Alprazolam Punto de fusion

    228-228.5oC

    Alprazolam H2O Solubilidad

    40 mg / L a pH 7, 12 mg / ml a pH 1,2

    Alprazolam Estado

    Solid

    Alprazolam LogP

    4.251

    Alprazolam Formas de dosificacion

    Comprimidos (0,25 mg, 0,5, 1 ó 2)

    Alprazolam Indicacion

    Para el manejo del trastorno de ansiedad o el alivio a corto plazo de síntomas de ansiedad y para el tratamiento del trastorno de pánico, con o sin agorafobia.

    Alprazolam Farmacologia

    Alprazolam, una benzodiacepina, se utiliza para tratar el trastorno de pánico y trastorno de ansiedad. A diferencia de clordiazepóxido, clorazepato, y prazepam, alprazolam tiene una vida media más corta y metabolitos con actividad mínima. Al igual que otras benzodiazepinas triazolo como triazolam, alprazolam puede tener interacciones farmacológicas importantes involucran el citocromo P-450 3A4 isoenzima. Clínicamente, todas las benzodiazepinas causan una relación dosis- relacionados con la actividad central de depresores del sistema nervioso que van desde un leve deterioro de la ejecución de la tarea a la hipnosis. A diferencia de otras benzodiazepinas, alprazolam también puede tener cierta actividad antidepresiva, aunque evidencia clínica de esta falta.

    Alprazolam Absorcion

    Absorbe fácilmente en el tracto gastrointestinal. La biodisponibilidad es del 80-90%.

    Alprazolam Toxicidad

    Ratón por vía oral, LD50 = 1020 mg / kg. Los síntomas de sobredosis incluyen confusión, coma, pérdida de la coordinación, somnolencia, y el tiempo lento de reacción.

    Alprazolam Informacion de Pacientes

    Alprazolam is used for the treatment of anxiety, panic disorder, and insomnia. Inform your physican if you are pregnant or nursing. Alprazolam may cause dizziness and drowsiness; use caution while driving or operating hazardous machinery. Do not take any other sedating drugs or drink alcohol while taking this medication. Alprazolam may be habit forming. Withdrawal symptoms may occur after you stop taking it. Alprazolam may be taken with or without food.

    For All Users of Alprazolam

    To assure safe and effective use of benzodiazepines, all patients prescribed alprazolam should be provided with the following guidance. In addition, panic disorder patients, for whom doses greater than 4 mg/day are typically prescribed, should be advised about the risks associated with the use of higher doses.

    1. Inform your physician about any alcohol consumption and medicine you are taking now, including medication you may buy without a prescription. Alcohol should generally not be used during treatment with benzodiazepines.

    2. Not recommended for use in pregnancy. Therefore, inform your physician if you are pregnant, if you are planning to have a child, or if you become pregnant while you are taking this medication.

    3. Inform your physician if you are nursing.

    4. Until you experience how this medication affects you, do not drive a car or operate potentially dangerous machinery, etc.

    5. Do not increase the dose even if you think the medication "does not work anymore" without consulting your physician. Benzodiazepines, even when used as recommended, may produce emotional and/or physical dependence.

    6. Do not stop taking this medication abruptly or decrease the dose without consulting your physician, since withdrawal symptoms can occur.

    Additional Advice for Panic Disorder Patients

    The use of alprazolam at doses greater than 4 mg/day, often necessary to treat panic disorder, is accompanied by risks that you need to carefully consider. When used at high doses greater than 4 mg/day, which may or may not be required for your treatment, alprazolam has the potential to cause severe emotional and physical dependence in some patients and these patients may find it exceedingly difficult to terminate treatment. In two controlled trials of 6 to 8 weeks duration where the ability of patients to discontinue medication was measured, 7-29% of patients treated with alprazolam did not completely taper off therapy. In a controlled postmarketing discontinuation study of panic disorder patients, the patients treated with doses of alprazolam greater than 4 mg/day had more difficulty tapering to zero dose than patients treated with less than 4 mg/day. In all cases, it is important that your physician help you discontinue this medication in a careful and safe manner to avoid overly extended use of alprazolam.

    In addition, the extended use at doses greater than 4 mg/day appears to increase the incidence and severity of withdrawal reactions when alprazolam is discontinued. These are generally minor but seizure can occur, especially if you reduce the dose too rapidly or discontinue the medication abruptly. Seizure can be life-threatening.

    Alprazolam Organismos afectados

    Humanos y otros mamíferos