dl-Acebutolol
dl-Acebutolol Brand names, dl-Acebutolol Analogs
dl-Acebutolol Brand Names Mixture
- No information avaliable
dl-Acebutolol Chemical_Formula
C18H28N2O4
dl-Acebutolol RX_link
http://www.rxlist.com/cgi/generic2/ace.htm
dl-Acebutolol fda sheet
dl-Acebutolol msds (material safety sheet)
dl-Acebutolol Synthesis Reference
No information avaliable
dl-Acebutolol Molecular Weight
336.426 g/mol
dl-Acebutolol Melting Point
119-123 oC
dl-Acebutolol H2O Solubility
259 mg/L
dl-Acebutolol State
Solid
dl-Acebutolol LogP
2.356
dl-Acebutolol Dosage Forms
Tablet; Capsule (200 mg and 400 mg)
dl-Acebutolol Indication
For the management of hypertension and ventricular premature beats in adults.
dl-Acebutolol Pharmacology
Acebutolol is a cardioselective, beta-adrenoreceptor blocking agent, which possesses mild intrinsic sympathomimetic activity (ISA) in its therapeutically effective dose range. In general, beta-blockers reduce the work the heart has to do and allow it to beat more regularly. Acebutolol has less antagonistic effects on peripheral vascular ß2-receptors at rest and after epinephrine stimulation than nonselective beta-antagonists. Low doses of acebutolol produce less evidence of bronchoconstriction than nonselective agents like propranolol but more than atenolol.
dl-Acebutolol Absorption
Well absorbed from the Gl tract with an absolute bioavailability of approximately 40% for the parent compound. In
dl-Acebutolol side effects and Toxicity
Symptoms of overdose include extreme bradycardia, advanced atrioventricular block, intraventricular conduction defects, hypotension, severe congestive heart failure, seizures, and in susceptible patients, bronchospasm, and hypoglycemia.
dl-Acebutolol Patient Information
dl-Acebutolol Organisms Affected
Humans and other mammals
