biperidine
Category
biperidine Brand names, biperidine Analogs
biperidine Brand Names Mixture
No information avaliable
biperidine Chemical_Formula
C21H29NO
biperidine RX_link
http://www.rxlist.com/cgi/generic2/biperiden.htm
biperidine fda sheet
biperidine msds (material safety sheet)
biperidine Synthesis Reference
No information avaliable
biperidine Molecular Weight
311.461 g/mol
biperidine Melting Point
114 oC
biperidine H2O Solubility
25.1 mg/L
biperidine State
Solid
biperidine LogP
3.85
biperidine Dosage Forms
Tablet
biperidine Indication
For use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy.
biperidine Pharmacology
Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. The parenteral form of biperiden is an effective and reliable agent for the treatment of acute episodes of extrapyramidal disturbances sometimes seen during treatment with neuroleptic agents. Akathisia, akinesia, dyskinetic tremors, rigor, oculogyric crisis, spasmodic torticollis, and profuse sweating are markedly reduced or eliminated. With parenteral biperiden, these drug-induced disturbances are rapidly brought under control.
biperidine Absorption
87% bioavailability
biperidine Toxicity
LD50=760 mg/kg (Orally in rats). Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
biperidine Patient Information
No information avaliable
biperidine Organisms Affected
Humans and other mammals
