Zeldox

• Antipsychotics
• Dopamine Antagonists
• Serotonin Antagonist
• ATC:N05AE04

• Geodon
• Zeldox

• No information avaliable

C₂₁H₂₁ClN₄OS

http://www.rxlist.com/cgi/generic2/ziprasidone.htm

Zeldox FDA

Zeldox MSDS

J. A. Lowe III, A. A. Nagel, Eur. pat. Appl. 281,309; eidem, U.S. pat. 4,831,031 (1988, 1989 both to Pfizer).

412.936 g/mol

>300 ^oC

No information avaliable

Solid

3.813

Capsule; Injection;

For the treatment of schizophrenia

Ziprasidone is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Ziprasidone is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), dopamine Type 2 (D2), 1 and 2 adrenergic, and H1 histaminergic receptors. Ziprasidone acts as an antagonist at other receptors, but with lower potency. Antagonism at receptors other than dopamine and 5HT2 with similar receptor affinities may explain some of the other therapeutic and side effects of Ziprasidone. Ziprasidone's antagonism of muscarinic M1-5 receptors may explain its anticholinergic effects. Ziprasidone's antagonism of histamine H1 receptors may explain the somnolence observed with this drug. Ziprasidone's antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug. Ziprasidone functions as an antagonist at the Dopamine D2 , 5HT-2A , and 5HT-1D receptors, and as an agonist at the 5HT-1A receptor. Ziprasidone also inhibits synaptic reuptake of serotonin and norepinephrine.

~60%

No information avaliable

Humans and other mammals