PharmacyCodes



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Zeffix Brand names, Zeffix Analogs

Zeffix Brand Names Mixture

  • Combivir (Lamivudine + Zidovudine)
  • Kivexa (Abacavir (Abacavir Sulfate) + Lamivudine)
  • Trizivir (Abacavir (Abacavir Sulfate) + Lamivudine + Zidovudine)

Zeffix Chemical_Formula

C8H11N3O3S

Zeffix RX_link

http://www.rxlist.com/cgi/generic3/lamivudine.htm

Zeffix fda sheet

Zeffix FDA

Zeffix msds (material safety sheet)

Zeffix MSDS

Zeffix Synthesis Reference

No information avaliable

Zeffix Molecular Weight

229.257 g/mol

Zeffix Melting Point

160-162 oC

Zeffix H2O Solubility

70 mg/ml

Zeffix State

Solid

Zeffix LogP

No information avaliable

Zeffix Dosage Forms

Solution; Tablet

Zeffix Indication

For the treatment of HIV infection and chronic hepatitis B (HBV).

Zeffix Pharmacology

Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). Lamivudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.

Zeffix Absorption

Lamivudine was rapidly absorbed after oral administration in HIV-infected patients. Absolute bioavailability in adults is 86% ± 16% for the tablet and 87% ± 13% for the oral solution.

Zeffix side effects and Toxicity

No information avaliable

Zeffix Patient Information

Zeffix Organisms Affected

Human immunodeficiency virus and Hepatitis B virus