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Vidarabine Brand names, Vidarabine Analogs

Vidarabine Brand Names Mixture

  • No information avaliable

Vidarabine Chemical_Formula

C10H15N5O5

Vidarabine RX_link

http://www.rxlist.com/cgi/generic3/vidarabine.htm

Vidarabine fda sheet

Vidarabine msds (material safety sheet)

Vidarabine Synthesis Reference

No information avaliable

Vidarabine Molecular Weight

285.257 g/mol

Vidarabine Melting Point

No information avaliable

Vidarabine H2O Solubility

No information avaliable

Vidarabine State

Solid

Vidarabine LogP

-2.115

Vidarabine Dosage Forms

No information avaliable

Vidarabine Indication

For treatment of chickenpox - varicella, herpes zoster and herpes simplex

Vidarabine Pharmacology

Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of Vidarabine is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Vidarabine into Vidarabine monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Vidarabine triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.

Vidarabine Absorption

No information avaliable

Vidarabine side effects and Toxicity

No information avaliable

Vidarabine Patient Information

No information avaliable

Vidarabine Organisms Affected

Human Herpes Viruses