Vehem
Vehem Brand names, Vehem Analogs
Vehem Brand Names Mixture
- No information avaliable
Vehem Chemical_Formula
C32H32O13S
Vehem RX_link
http://www.rxlist.com/cgi/generic2/teniposide.htm
Vehem fda sheet
Vehem msds (material safety sheet)
Vehem Synthesis Reference
No information avaliable
Vehem Molecular Weight
656.655 g/mol
Vehem Melting Point
No information avaliable
Vehem H2O Solubility
No information avaliable
Vehem State
Solid
Vehem LogP
1.963
Vehem Dosage Forms
Liquid
Vehem Indication
Treatment of refractory acute lymphoblastic leukaemia
Vehem Pharmacology
Teniposide is a phase-specific cytotoxic drug, acting in the late S or early G 2 phase of the cell cycle, thus preventing cells from entering mitosis. Teniposide causes dose-dependent single- and double-stranded breaks in DNA and DNA: protein cross-links. The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA.
Vehem Absorption
No information avaliable
Vehem side effects and Toxicity
No information avaliable
Vehem Patient Information
No information avaliable
Vehem Organisms Affected
Humans and other mammals
