Valnac
Category
Valnac Brand names, Valnac Analogs
Valnac Brand Names Mixture
- Lotrisone (betamethasone + clotrimazole)
Valnac Chemical_Formula
C22H29FO5
Valnac RX_link
http://www.rxlist.com/cgi/generic2/betamet.htm
Valnac fda sheet
Valnac msds (material safety sheet)
Valnac Synthesis Reference
Taub et al., J. Am. Chem. Soc. 80, 4435 (1958)
Valnac Molecular Weight
392.461 g/mol
Valnac Melting Point
231-234oC
Valnac H2O Solubility
Insoluble
Valnac State
Solid
Valnac LogP
1.772
Valnac Dosage Forms
Oral Solution; Tablet; Solution for Injection; Injectable Suspension; Cream; Gel; Ointment; Foam; Lotion
Valnac Indication
Topical use (cream, lotion and ointment): for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
Topical use (foam): relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp
Systemic use: for the treatment of edocrine disorders, rheumatic disorders, collagen diseases, dermatological diseases, allergic states, ophthalmic diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, gastrointestinal diseases, tuberculous meningitis and trichinosis.
Valnac Pharmacology
Betamethasone and its derivatives, betamethasone sodium phosphate and betamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties, betamethasone is combined with a mineralocorticoid to manage adrenal insufficiency and is used in the form of betamethasone benzoate, betamethasone dipropionate, or betamethasone valerate for the treatment of inflammation due to corticosteroid-responsive dermatoses. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections.
Valnac Absorption
Minimal if applied topically.
Valnac side effects and Toxicity
Symptoms of overdose include burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria.
Valnac Patient Information
Patients using topical corticosteroids should receive the following information and instructions. This information
is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse
or intended effects.
1. This medication is to be used as directed by the physician and should not be used longer than the prescribed
time period. It is for external use only. Avoid contact with the eyes.
2. Patients should be advised not to use this medication for any disorder other than that for which it was
prescribed.
3. The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive.
4. Patients should report any signs of local adverse reactions.
5. Other corticosteroid-containing products should not be used with DIPROLENE AF Cream without first talking to
your physician.
Valnac Organisms Affected
Humans and other mammals