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Valacyclovir Brand names, Valacyclovir Analogs

Valacyclovir Brand Names Mixture

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Valacyclovir Chemical_Formula


Valacyclovir RX_link

Valacyclovir fda sheet

Valacyclovir FDA

Valacyclovir msds (material safety sheet)

Valacyclovir MSDS

Valacyclovir Synthesis Reference

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Valacyclovir Molecular Weight

324.336 g/mol

Valacyclovir Melting Point

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Valacyclovir H2O Solubility

No information avaliable

Valacyclovir State


Valacyclovir LogP

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Valacyclovir Dosage Forms


Valacyclovir Indication

For the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals.

Valacyclovir Pharmacology

Valacyclovir is a prodrug and synthetic purine nucleoside analogue with inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Valacyclovir is almost completely converted to acyclovir and L-valine. The inhibitory activity of valacyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, which is then converted into acyclovir diphosphate and triphosphate by cellular enzymes. Acyclovir is selectively converted to the active triphosphate form by cells infected with herpes viruses.

Valacyclovir Absorption

After oral administration, valacyclovir hydrochloride is rapidly absorbed from the gastrointestinal tract. The absolute bioavailability of acyclovir after administration of valacyclovir is 54.5% ± 9.1%.

Valacyclovir side effects and Toxicity

Adverse effects of overexposure might include headache and nausea.

Valacyclovir Patient Information

Valacyclovir Organisms Affected

Human herpes virus