Unipen

Unipen Brand names, Unipen Analogs

Unipen Brand Names Mixture

No information avaliable

Unipen Chemical_Formula

C₃₃H₄₇NO₁₃

Unipen RX_link

http://www.rxlist.com/cgi/generic2/natamycin.htm

Unipen fda sheet

Unipen msds (material safety sheet)

Unipen Synthesis Reference

No information avaliable

Unipen Molecular Weight

665.725 g/mol

Unipen Melting Point

290 ^oC

Unipen H₂O Solubility

4100 mg/L

Unipen State

Solid

Unipen LogP

0.495

Unipen Dosage Forms

Ophthalmic suspension (5%)

Unipen Indication

For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.

Unipen Pharmacology

Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.

Unipen Absorption

Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.

Unipen side effects and Toxicity