U-plasminogen activator
U-plasminogen activator Brand names, U-plasminogen activator Analogs
U-plasminogen activator Brand Names Mixture
- No information avaliable
U-plasminogen activator Chemical_Formula
C1376H2145N383O406S18
U-plasminogen activator RX_link
http://www.rxlist.com/cgi/pharmclips2.cgi?keyword=%20Abbokinase%AE
U-plasminogen activator fda sheet
U-plasminogen activator msds (material safety sheet)
U-plasminogen activator Synthesis Reference
PMID 2987867
U-plasminogen activator Molecular Weight
31126.5
U-plasminogen activator Melting Point
76 oC at pH 4.5 (Nowak, U.K. et al., Biochemistry 33:2951-2960 (1994).
U-plasminogen activator H2O Solubility
No information avaliable
U-plasminogen activator State
Liquid
U-plasminogen activator LogP
-0.466
U-plasminogen activator Dosage Forms
Powder for solution; Solution (IV infusion)
U-plasminogen activator Indication
For the treatment of pulminary embolism, coronary artery thrombosis and IV catheter clearance
U-plasminogen activator Pharmacology
Urokinase is used for the treatment of pulmonary embolisms. The low molecular weight form of human urokinase consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Urokinase is an enzyme (protein) produced by the kidney, and found in the urine. There are two forms of urokinase which differ in molecular weight but have similar clinical effects. Urokinase is the low molecular weight form. Urokinase acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen and some other plasma proteins.
U-plasminogen activator Absorption
No information avaliable
U-plasminogen activator side effects and Toxicity
No information avaliable
U-plasminogen activator Patient Information
http://www.drugs.com/PDR/Abbokinase.html
U-plasminogen activator Organisms Affected
Humans and other mammals
