Tysabri (Antegren) Biogen
Tysabri (Antegren) Biogen Brand names, Tysabri (Antegren) Biogen Analogs
Tysabri (Antegren) Biogen Brand Names Mixture
- No information avaliable
Tysabri (Antegren) Biogen Chemical_Formula
No information avaliable
Tysabri (Antegren) Biogen RX_link
http://www.rxlist.com/cgi/generic3/tysabri.htm
Tysabri (Antegren) Biogen fda sheet
Tysabri (Antegren) Biogen msds (material safety sheet)
Tysabri (Antegren) Biogen Synthesis Reference
Sequence listed in Leger OJ, Yednock TA, Tanner L, Horner HC, Hines DK, Keen S, Saldanha J, Jones ST, Fritz LC, Bendig MM. Humanization of a mouse antibody against human alpha-4 integrin: a potential therapeutic for the treatment of multiple sclerosis. Hum Antibodies. 1997;8(1):3-16
Tysabri (Antegren) Biogen Molecular Weight
No information avaliable
Tysabri (Antegren) Biogen Melting Point
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).
Tysabri (Antegren) Biogen H2O Solubility
No information avaliable
Tysabri (Antegren) Biogen State
Liquid
Tysabri (Antegren) Biogen LogP
No information avaliable
Tysabri (Antegren) Biogen Dosage Forms
Solution (IV Infusion)
Tysabri (Antegren) Biogen Indication
For treatment of multiple sclerosis
Tysabri (Antegren) Biogen Pharmacology
In multiple sclerosis, lesions are believed to occur when activated inflammatory cells, including T-lymphocytes, cross the blood-brain barrier (BBB). Leukocyte migration across the BBB involves interaction between adhesion molecules on inflammatory cells, and their counter-receptors present on endothelial cells of the vessel wall. The clinical effect of natalizumab in multiple sclerosis may be a secondary result of its blockade of the molecular interaction of a 4b 1-integrin expressed by inflammatory cells with VCAM-1 on vascular endothelial cells, and with CS-1 and/or osteopontin expressed by parenchymal cells in the brain.
Tysabri (Antegren) Biogen Absorption
No information avaliable
Tysabri (Antegren) Biogen side effects and Toxicity
No information avaliable
Tysabri (Antegren) Biogen Patient Information
BIOD00083.html
Tysabri (Antegren) Biogen Organisms Affected
Humans and other mammals
