Tysabri
Tysabri Brand names, Tysabri Analogs
Tysabri Brand Names Mixture
- No information avaliable
Tysabri Chemical_Formula
No information avaliable
Tysabri RX_link
http://www.rxlist.com/cgi/generic3/tysabri.htm
Tysabri fda sheet
Tysabri msds (material safety sheet)
Tysabri Synthesis Reference
Sequence listed in Leger OJ, Yednock TA, Tanner L, Horner HC, Hines DK, Keen S, Saldanha J, Jones ST, Fritz LC, Bendig MM. Humanization of a mouse antibody against human alpha-4 integrin: a potential therapeutic for the treatment of multiple sclerosis. Hum Antibodies. 1997;8(1):3-16
Tysabri Molecular Weight
No information avaliable
Tysabri Melting Point
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).
Tysabri H2O Solubility
No information avaliable
Tysabri State
Liquid
Tysabri LogP
No information avaliable
Tysabri Dosage Forms
Solution (IV Infusion)
Tysabri Indication
For treatment of multiple sclerosis
Tysabri Pharmacology
In multiple sclerosis, lesions are believed to occur when activated inflammatory cells, including T-lymphocytes, cross the blood-brain barrier (BBB). Leukocyte migration across the BBB involves interaction between adhesion molecules on inflammatory cells, and their counter-receptors present on endothelial cells of the vessel wall. The clinical effect of natalizumab in multiple sclerosis may be a secondary result of its blockade of the molecular interaction of a 4b 1-integrin expressed by inflammatory cells with VCAM-1 on vascular endothelial cells, and with CS-1 and/or osteopontin expressed by parenchymal cells in the brain.
Tysabri Absorption
No information avaliable
Tysabri side effects and Toxicity
No information avaliable
Tysabri Patient Information
BIOD00083.html
Tysabri Organisms Affected
Humans and other mammals
