Triludan
Category
Triludan Brand names, Triludan Analogs
Triludan Brand Names Mixture
Triludan Chemical_Formula
C32H41NO2
Triludan RX_link
http://www.rxlist.com/cgi/generic/terfen.htm
Triludan fda sheet
Triludan msds (material safety sheet)
Triludan Synthesis Reference
A. A. Carr, C. R. Kinsolving, U.S. Pat. 3,878,217 (1975)
Triludan Molecular Weight
471.673 g/mol
Triludan Melting Point
146.5-148.5oC
Triludan H2O Solubility
10 mg/L
Triludan State
Solid
Triludan LogP
7.784
Triludan Dosage Forms
Oral tablets
Triludan Indication
For the treatment of allergic rhinitis, hay fever, and allergic skin disorders.
Triludan Pharmacology
Terfenadine, an H1-receptor antagonist antihistamine, is similar in structure to astemizole and haloperidol, a butyrophenone antipsychotic. The active metabolite of terfenadine is fexofenadine.
Triludan Absorption
On the basis of a mass balance study using 14C labeled terfenadine the oral absorption of terfenadine was estimated to be at least 70%
Triludan side effects and Toxicity
Mild (e.g., headache, nausea, confusion), but adverse cardiac events including cardiac arrest, ventricular arrhythmias including torsades de pointes and QT prolongation have been reported. LD50=mg/kg (orally in mice)
Triludan Patient Information
Triludan Organisms Affected
Humans and other mammals
