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Trazonil
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Trazonil Brand names, Trazonil Analogs

Trazonil Brand Names Mixture

  • No information avaliable

Trazonil Chemical_Formula

C19H22ClN5O

Trazonil RX_link

http://www.rxlist.com/cgi/generic/traz.htm

Trazonil fda sheet

Trazonil FDA

Trazonil msds (material safety sheet)

Trazonil Synthesis Reference

Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)

Trazonil Molecular Weight

371.864 g/mol

Trazonil Melting Point

86-87 oC

Trazonil H2O Solubility

Sparigly soluble

Trazonil State

Solid

Trazonil LogP

2.553

Trazonil Dosage Forms

Tablet

Trazonil Indication

For the treatment of depression.

Trazonil Pharmacology

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.

Trazonil Absorption

Well absorbed following oral administration.

Trazonil side effects and Toxicity

LD50=96mg/kg (i.v. in mice)

Trazonil Patient Information

Trazonil Organisms Affected

Humans and other mammals