Trazodone Hcl
Trazodone Hcl Brand names, Trazodone Hcl Analogs
Trazodone Hcl Brand Names Mixture
- No information avaliable
Trazodone Hcl Chemical_Formula
C19H22ClN5O
Trazodone Hcl RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Trazodone Hcl fda sheet
Trazodone Hcl msds (material safety sheet)
Trazodone Hcl Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Trazodone Hcl Molecular Weight
371.864 g/mol
Trazodone Hcl Melting Point
86-87 oC
Trazodone Hcl H2O Solubility
Sparigly soluble
Trazodone Hcl State
Solid
Trazodone Hcl LogP
2.553
Trazodone Hcl Dosage Forms
Tablet
Trazodone Hcl Indication
For the treatment of depression.
Trazodone Hcl Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Trazodone Hcl Absorption
Well absorbed following oral administration.
Trazodone Hcl side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Trazodone Hcl Patient Information
Trazodone Hcl Organisms Affected
Humans and other mammals
